Methylprednisolone Sodium Succinate Combined with Tiotropium Bromide on the Improvement of Blood Gas and Inflammation Indicators in Patients with AECOPD
Objective To analyze the effect of methylprednisolone sodium succinate combined with tiotropium bromide on blood gas and inflammation indicators in patients with acute exacerbation of chronic obstructive pulmonary disease(AECOPD).Methods A total of 120 patients with AECOPD in Shangqiu Hospital of Traditional Chinese Medicine from October 2020 to October 2023 were retrospectively selected,and they were divided into experimental group and conventional group according to different treatment methods,with 60 cases in each group.On the basis of conventional treatment,the conventional group was treated with tiotropium bromide,and the experimental group was treated with methylprednisolone sodium succinate combined with tiotropium bromide,both of which were treated for 2 weeks.The clinical efficacy,blood gas indexes,lung function,inflammatory indexes and adverse reactions were compared between the two groups.Results The total effective rate of the experimental group was 88.33％higher than that of the conventional group(73.33％)(P＜0.05);compared with the two groups before treatment,the arterial partial pressure of oxygen(PaO2)and blood pH increased and the partial pressure of carbon dioxide(PaCO2)decreased after 2 weeks of treatment,and the improvement range in the experimental group was higher than that in the conventional group(P＜0.05).After 2 weeks of treatment,forced expiratory volume in 1 second(FEV1),FEV1/forced vital capacity(FEV1/FVC),the maximum expiratory flow rate(PEF)increased in the experimental group(P＜0.05),serum interleukin-8(IL-8),tumor necrosis factor-α(TNF-α),complement 1q/tumor necrosis factor-related protein 5(CTRP5),The level of chemokine ligand 12(CXCL12)showed a downward trend,but the decrease in the experimental group were more than those in the conventional group(P＜0.05).There was no significant difference in adverse reactions between the two groups(P＞0.05).Conclusion Methylprednisolone sodium succinate combined with tiotropium bromide can effectively improve blood gas indexes,lung function,and reduce lung inflammation in patients with AECOPD.
Acute exacerbation of chronic obstructive pulmonary diseaseMethylprednisolone sodium succinateTiotropium bromideBlood gas index
万方数据
维普
