Current Status and Rationality Evaluation of Postoperative Use of Nonsteroidal Anti-inflammatory Drugs in 267 Patients Undergoing Major Lung Surgery
Objective Investigate the current use of nonsteroidal anti-inflammatory drugs (NSAIDs) in the thoracic surgery department of Changshu Hospital Affiliated to Soochow University,to provide a reference for promoting rational drug use in clinical settings. Methods A retrospective survey was conducted to obtain medical records of patients who underwent major lung surgery in the thoracic surgery department from January 1 to December 31,2022,from the information platform of hospital. Based on the drug instructions,diagnosis and treatment guidelines,expert consensus,etc.,the rationality of NSAIDs medication was evaluated. Cases of unreasonable use of NSAIDs were classified as the observation group,and those who did not experience unreasonable use were set as the control group. The incidence of NSAIDs related adverse reactions (ADRs) and the length of hospital stay were compared between the two groups. Results The total number of cases included was 267,with 148 in the observation group and 119 in the control group. The observation group had 59 cases of NSAIDs related ADR,with an incidence rate of 39.86％,while the control group had 31 cases of NSAIDs related ADR,with an incidence rate of 26.05％. The incidence rate of NSAIDs related ADR in the observation group was higher than that in the control group,and the difference was statistically significant (x2=5.63,P=0.018). The average length of hospital stay in the observation group was longer than that in the control group,the difference was statistically significant (P<0.001). Conclusion Unreasonable use of NSAIDs after lung surgery increases the risk of NSAID related ADRs and can also lead to prolonged hospital stay for patients.
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