Effect of Thioctic Acid Combined with Pentoxifylline on Nerve Conduction Velocity in Elderly Patients with Diabetic Peripheral Neuropathy
Objective To study the effect of thioctic acid combined with pentoxifylline on nerve conduction velocity in elderly patients with diabetic peripheral neuropathy (DPN). Methods Ninety-two elderly patients with DPN were prospectively selected and treated in Henan (Zhengzhou) Modern Medical Research Institute Traditional Chinese Medicine Hospital from January 2022 to December 2023. They were randomly divided into a combined group of 48 patients and a single group of 44 patients using a random number table method. The single group was treated with pentoxifylline,while the combined group was treated with thioctic acid combined with pentoxifylline. The clinical efficacy,median nerve F-wave,Toronto Clinical Scoring System (TCSS) and Michigan Neuropathy Screening Instrument (MNSI) scores,oxidative stress indicators,and total incidence of adverse reactions were compared between the two groups. Results The total effective rate of the combined group (93.75％) was higher than that of the single group (77.27％) (P<0.05),and there was no significant difference in the total incidence of adverse reactions between the two groups (P>0.05);after treatment,the F-wave,oxidative stress index,TCSS,and MNSI scores of the two groups improved,and the combined group was superior to the single group (P<0.05). Conclusion Thioctic acid combined with pentoxifylline in the treatment of elderly patients with DPN has significant effect,can effectively improve nerve conduction velocity,reduce oxidative stress reaction,and has certain safety.
万方数据
维普
