The Application Value of Dexmedetomidine Combined with Sevoflurane in Cervical Cancer Surgery
Objective To investigate the efficacy of dexmedetomidine combined with sevoflurane in cervical cancer surgery and its impact on cognitive function. Methods Based on the principle of pairing,68 patients who underwent cervical cancer surgery in Puyang Maternal and Child Health Hospital from January 2021 to January 2024 were retrospectively selected and divided into a control group (n=34) and an observation group (n=34) according to different anesthesia schemes. The patients who were anesthetized with sevoflurane were included in the control group,and the patients who were anesthetized with dexmedetomidine combined with sevoflurane were included in the observation group. The quality of anesthesia recovery (stay in the recovery room,recovery time,and extubation time),end-tidal sevoflurane concentration and sevoflurane dose at each time point[skin incision (T1),10 minutes after the start of pneumoperitoneum (T2),and at the end of surgery (T3)],Visual Analogue Scale (VAS) scores at different time points,the degree of cognitive dysfunction before and 1-3 days after surgery,inflammation-related indicators[high mobility group box 1 protein (HMGB1),interleukin-6 (IL-6)]before and 1 day after surgery,and adverse reactions were compared between the two groups. Results The observation group had a shorter recovery time from anesthesia,extubation,and stay in the anesthesia recovery room compared to the control group (P<0.05). The sevoflurane concentration in the observation group was lower than that in the control group at T1-T3,and the sevoflurane dose was less than that in the control group (P<0.05). The VAS scores at 6,12,and 24 hours in the observation group were lower than those in the control group (P<0.05). The MMSE scores of the observation group were higher than those of the control group on postoperative days 1,2,and 3 (P<0.05). The levels of IL-6 and HMGB1 in the observation group were lower than those in the control group on day 1 after surgery (P<0.05). The total incidence of adverse reactions in the observation group was 14.71％,which was not significantly different from the control group's 8.82％ (P>0.05). Conclusion Dexmedetomidine combined with sevoflurane anesthesia can effectively enhance the analgesic effect,reduce the amount of sevoflurane used,alleviate postoperative cognitive impairment and inflammatory injury,improve the quality of recovery,and ensure the safety of anesthesia.
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