首页|Bakri子宫填塞球囊联合卡贝缩宫素对宫缩乏力性产后出血患者出血量及卵巢功能的影响

Bakri子宫填塞球囊联合卡贝缩宫素对宫缩乏力性产后出血患者出血量及卵巢功能的影响

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目的 探讨Bakri子宫填塞球囊联合卡贝缩宫素对宫缩乏力性产后出血患者的影响。方法 随机数字表法将2022年1月至2023年12月景德镇市第三人民医院收治的80例宫缩乏力性产后出血患者分为两组。对照组(n=40例)予以卡贝缩宫素治疗,观察组(n=40例)在对照组基础上加用Bakri子宫填塞球囊治疗。对比两组止血起效时间、体征情况、凝血功能、应激指标、卵巢功能、不良反应发生情况。结果 治疗2 h、24 h后,观察组出血量少于对照组,止血起效时间短于对照组,差异有统计学意义(P<0。05);两组各项体征指标对比,差异无统计学意义(P>0。05);观察组的活化部分凝血活酶时间(APTT)、雌二醇(E2)、凝血酶原时间(PT)水平均高于对照组,肾上腺素(E)、纤维蛋白原(FIB)、血管紧张素Ⅱ、D-二聚体(D-D)、去甲肾上腺素(NE)、黄体生成素(LH)、卵泡生成激素(FSH)水平均低于对照组,差异有统计学意义(P<0。05);两组不良反应发生率相当,差异无统计学意义(P>0。05)。结论 Bakri子宫填塞球囊联合卡贝缩宫素治疗效果显著,可缩短止血起效时间,改善凝血功能,减轻机体应激反应,有利于提高患者卵巢功能,且安全性高。
Effect of Bakri Uterine Tamponade Balloon Combined with Carbetocin on Blood Loss and Ovarian Function in Patients with Uterine Atony Postpartum Hemorrhage
Objective To investigate the effect of Bakri uterine tamponade balloon combined with carbetocin on patients with uterine atony postpartum hemorrhage. Methods 80 patients with postpartum hemorrhage treated in The Third People's Hospital of Jingdezhen from January 2022 to December 2023 were divided into two groups. The control group (n=40 cases) was treated with carbetocin,and the observation group (n=40 cases) was treated with Bakri uterine tamponade balloon based on the control group. The onset time of hemostasis,physical signs,coagulation function,stress index,ovarian function,and the occurrence of adverse reactions were compared. Results After 2 h and 24 h of treatment,The observation group had less bleeding volume than the control group,the onset time of hemostasis was shorter than that of the control group (P<0.05);there was no difference in the physical signs between the two groups (P>0.05);the activated partial thromboplastin time (APTT),estradiol (E2),prothrombin time (PT) levels were higher than the control group,the levels of epinephrine (E),fibrinogen (FIB),angiotensin,D-dimer (D-D),noradrenaline (NE),luteizing hormone (LH),and folliculogenic hormone (FSH) were lower than those of the control group (P<0.05);the incidence of adverse effects was comparable in the two groups (P>0.05). Conclusion Bakri uterine tamponade balloon combined with carbetocin has a remarkable effect,which can shorten the onset time of hemostasis,improve coagulation function,reduce the body stress response,and is conducive to improving the ovarian function of patients,with high safety.

Uterine atony postpartum hemorrhageCarbetocinBakri uterine tamponade balloonOvarian functionBlood lossCoagulation function

徐晓园、黎招华

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景德镇市第三人民医院,江西景德镇 333000

宫缩乏力性产后出血 卡贝缩宫素 Bakri子宫填塞球囊 卵巢功能 出血量 凝血功能

2024

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江西省药学会

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影响因子:0.672
ISSN:1672-2809
年,卷(期):2024.21(8)