Analysis of Risk Factors for Phlebitis During Infusion of Propacetamol
Objective To explore the risk factors related to phlebitis caused by intravenous infusion of propacetamol injection in patients,and to provide a basis for taking targeted preventive measures. Methods Patients who were hospitalized in Zhengzhou Second People's Hospital and used propacetamol hydrochloride from December 2023 to April 2024 were selected. Through the inpatient pharmaceutical monitoring system,electronic medical record system,and clinical pharmacist monitoring records during the patient's hospitalization,130 patients were sorted and summarized. Occurrence of phlebitis,gender,age,BMI,smoking history,history of underlying diseases,whether pH buffers are used,solvent dosage,course of treatment,infusion speed,administration frequency,and whether aescin is combined. Single-factor analysis and multi-factor logistic regression analysis methods were used to study and analyze the influencing factors of phlebitis. Results Among the patients who received propacetamol injection with conventional infusion rate,74 cases (56.92％) developed phlebitis. Univariate analysis showed that age (x2=11.22,P=0.024),whether they had diabetes (x2=5.14,P=0.023),whether you suffer from hypertension (x2=7.84,P=0.005),whether you use aescin in combination (x2=6.20,P=0.013),whether you use pH regulators (x2=13.14,P<0.001) and solvent amount (x2=19.53,P<0.001) have statistically significant differences in the incidence of phlebitis.The results of logistic multivariate regression analysis showed that age (31-45) years,combined with the use of aescin for intravenous infusion of propatacemol are risk factors for phlebitis,the use of buffer,and the choice of 250 mL of solvent volume were the risk factors for intravenous infusion of propatamol. Protective factors for the development of phlebitis. Conclusion Increasing the pH value can reduce the incidence of phlebitis with propacetamol. Medicine,pharmaceutical and nursing should be integrated to ensure the rational clinical use of propacetamol and reduce the incidence of phlebitis.
万方数据
维普
