Based on the Intestinal Mucosal Barrier Function and Oxidative Stress Response,Analysis the Effect of the Combination of Azathioprine and Sulfasalazine in the Treatment of Ulcerative Colitis
Objective To analyze the effect of the combination of azathioprine and sulfasalazine in the treatment of ulcerative colitis (UC) based on intestinal mucosal barrier function and oxidative stress response. Methods 182 patients with UC in Xuchang Hospital from January 2019 to October 2022 were selected and randomly divided into two groups,each with 91 cases,according to a random number table method. The conventional group was given sulfasalazine,and on this basis,the experimental group was given azathioprine. The efficacy,symptom improvement,intestinal mucosal barrier function[D-lactate (D-LA),diamine oxidase (DAO),endotoxin (BT)],oxidative stress response[malondialdehyde (MDA),glutathione peroxidase (GSH-Px),superoxide dismutase (SOD)],and adverse reactions were compared between the two groups. Results After 3 months of continuous treatment,the total effective rate of the experimental group was higher than that of the conventional group (P<0.05);the disappearance time of diarrhea and bloody stool in the experimental group was shorter than that in the conventional group (P<0.05);the Sutherland score in the experimental group was lower than that in the conventional group (P<0.05);the levels of BT,DAO,D-LA,and MDA in the experimental group were lower than those in the conventional group,while the levels of GSH-Px and SOD were higher than those in the conventional group (P<0.05). There was no significant difference in the incidence of adverse reactions between the two groups (P>0.05). Conclusion The combination of azathioprine and sulfasalazine is safe and effective in the treatment of UC and protects the intestinal mucosal barrier and reduces oxidative stress.
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