Effects of Terlipressin Combined with Rabeprazole on Coagulation Function and Serum Inflammatory Factors in Patients with Liver Cirrhosis Complicated with Esophagogastric Variceal Bleeding
Objective To analyze the effects of terlipressin combined with rabeprazole on the coagulation function and serum inflammatory factor levels in patients with liver cirrhosis (LC) complicated with esophagogastric variceal bleeding (EGVB). Methods A total of 80 patients with LC complicated with EGVB who were treated in The Fifth People's Hospital of Anyang from May 2021 to July 2023 were selected and divided into control group (40 cases) and observation group (40 cases) according to different treatment schemes. Among them,40 cases were given rabeprazole as the control group,and 40 cases were given terlipressin combined with rabeprazole as the observation group. The clinical efficacy of the two groups were compared,as well as the levels of coagulation and fibrinolysis function,portal hemodynamics,serum inflammatory factors before and after treatment,and the incidence of adverse reactions was also compared between the two groups. Results The clinical total effective rate of the observation group was 95.00％ higher than 77.50％ of the control group (P<0.05). After treatment,the improvement of coagulation and fibrinolysis function in the observation group was better than that in the control group (P<0.05);the hemodynamics of portal vein system in the observation group was lower than that in the control group (P<0.05);the reduction of serum inflammatory factors in the observation group was greater than that in the control group (P<0.05). The incidence of adverse reactions in the observation group was 17.50％ compared with 7.50％ in the control group,with no significant difference (P>0.05). Conclusion Terlipressin combined with rabeprazole has obvious curative effect in the treatment of LC complicated with EGVB,which can regulate the coagulation and fibrinolysis function,improve the hemodynamics of portal vein system,reduce the inflammatory reaction,and has certain safety.
TerlipressinRabeprazoleLiver cirrhosisEsophagogastric variceal bleedingCoagulation function
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