首页|Hepatoprotective potential of ethanolic extract ofZiziphus oenoplia (L.) Mill roots against antitubercular drugs induced hepatotoxicity in experimental models
Hepatoprotective potential of ethanolic extract ofZiziphus oenoplia (L.) Mill roots against antitubercular drugs induced hepatotoxicity in experimental models
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ABSTRACT Objective:To evaluate the hepatoprotective potential of ethanolic (50%) extract ofZiziphus oenoplia (L.) Mill (Z. oenoplia) root against isoniazid(INH) and rifampicin(RIF) induced liver damage in animal models.Methods: Five groups of six rats each were selected for the study. Ethanolic extract at a dose of 150 and300 mg/kg as well as silymarin (100 mg/kg) were administered orally once daily for21d in INH + RIF treated groups. The serum levels of glutamic oxaloacetic transaminase(SGOT), glutamate pyruvate transaminase (SGPT), alkaline phosphatase (SALP), and bilirubin were estimated along with activities of superoxide dismutase, catalase, glutathione S-transferase, glutathione peroxidase, and hepatic melondialdehyde formation. Histopathological analysis was carried out to assess injury to the liver.Result: The considerably elevated serum enzymatic activities of glutamic oxaloacetic transaminase, glutamate pyruvate transaminase, alkaline phosphatase and bilirubin due toINH + RIF treatment were restored towards normal in a dose dependent manner after the treatment with ethanolic extract of Z. oenopliaroots. Meanwhile, the decreased activities of superoxide dismutase, catalase, glutathione S-transferase and glutathione peroxidase were also restored towards normal dose dependently. In addition, ethanolic extract also significantly prevented the elevation of hepatic melondialdehyde formation in the liver ofINH + RIF intoxicated rats in a dose dependent manner. The biochemical observations were supplemented with histopathological examination of rat liver sections.Conclusions: The results of this study strongly indicate that ethanolic extract of Z. oenoplia has a potent hepatoprotective action againstINH + RIF induced hepatic damage in rats.
Ch V Rao、AKS Rawat、Anil P Singh、Arpita Singh、Neeraj Verma
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Pharmacognosy and Ethnopharmacology Division, National Botanical Research Institute Council of Scientific and Industrial Research, Rana Pratap Marg, P.0. Box No. 436, Lucknow 226001, Uttar Pradesh, India
Department of Pharmacology, Goel Institute of Pharmacy & Sciences, Faizabad Road Near Indira Canal Lucknow 227105, Uttar Pradesh, India
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