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Recombinant vaccines:Current updates and future prospects

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Recombinant technology-based vaccines have emerged as a highly effective way to prevent a wide range of illnesses.The technology improved vaccine manufacturing,rendering it more efficient and economical.These vaccines have multiple advantages compared to conventional vaccines.The pandemic has heightened awareness of the advantages of these vaccine technologies;trust and acceptance of these vaccines are steadily growing globally.This work offers an overview of the prospects and advantages associated with recombinant vaccines.Additionally,it discusses some of the challenges likely to arise in the future.Their ability to target diverse pathogen classes underscores their contributions to preventing previously untreatable diseases(especially vector-borne and emerging diseases)and hurdles faced throughout the vaccine development process,especially in enhancing the effectiveness of these vaccines.Moreover,their compatibility with emerging vaccination platforms of the future like virus-like particles and CRISPR/Cas9 for the production of next-generation vaccines may offer many prospects.This review also reviewed the hurdles faced throughout the vaccine development process,especially in enhancing the effectiveness of these vaccines against vector-borne diseases,emerging diseases,and untreatable diseases with high mortality rates like AIDS as well as cancer.

MalariaDengueEmerging diseasesImmunoinformaticsVirus-like particlesCRISPR-Cas9

Vivek Kumar、Anuj Verma、Riddhi Singh、Priyanshi Garg、Santosh Kumar Sharma、Himanshu Narayan Singh、Santosh Kumar Mishra、Sanjay Kumar

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Department of Allied Medical Sciences,School of Allied Medical Sciences,Lovely Professional University,Phagwara,Punjab,India

Bioengineering,Division of Department of Bioscience and Biomedical Engineering,Indian Institute of Technology Bhilai,Chhattisgarh,India

Department of Biotechnology,IMS Engineering College,Ghaziabad,U.P.,India

Department of Chemistry and Biochemistry,University of Windsor,Ontario N9B3P4,Canada

Biological and Biocomputational Laboratory,Department of Life Sciences,Sharda School of Basic Sciences and Research,Sharda University,Greater Noida,U.P.,India

Department of System Biology,Columbia University Irving Medical Center,New York,NY 10032,USA

Department of Life Sciences,Sharda School of Basic Sciences and Research,Sharda University,Greater Noida,U.P.,India

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2024

10.4103/apjtm.apjtm_854_23

亚太热带医药杂志(英文版)

亚太热带医药杂志(英文版)

ISSN：
年,卷(期)：2024.17(8)