首页|Epidemiological observations of invasive group B Streptococcus infections in six major hospitals in Peninsular Malaysia

Epidemiological observations of invasive group B Streptococcus infections in six major hospitals in Peninsular Malaysia

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Objective:To address the lack of research on invasive group B Streptococcus(GBS)infections in Malaysia and Southeast Asia through a comprehensive analysis of GBS isolates obtained from hospitals.Methods:Medical records from patients with GBS infection isolated from the sterile site,such as blood and cerebrospinal fluid from 14 July 2019 to 15 December 2020,were reviewed from six major hospitals in Peninsular Malaysia.Inclusion criteria were invasive GBS,sterile sites and non-repeated GBS isolated from the same patients in the same admission.Viable isolates were re-identified for GBS and serotyped.Results:A total of 118 patients were eligible,with a majority of non-pregnant adults(76.3%).Over half of the patients(62.7%)had underlying medical conditions,with diabetes as the most common disease,followed by respiratory disease,renal disease,cardiovascular disease and skin and soft tissue disease.The most common manifestations were sepsis,followed by soft tissue abscess,diabetic foot ulcer,wet gangrene and cellulitis.The overall mortality was 7.6%.The most common serotype was serotype Ⅴ.Conclusions:Invasive GBS infection among non-pregnant adults showed a rising trend,particularly among diabetic individuals.The study underscores the importance of reducing risk factors and highlights the necessity of developing GBS vaccination as a preventive strategy for both infants and adults.

Streptococcus agalactiaeGroup B StreptococcusInvasive GBS infectionsMalaysia

AbdulRahman Muthanna、Mohd Nasir Mohd Desa、Nurul Asyikin Abdul Rahman、Nurul Diana Dzaraly、Nurul Hana Zainal Baharin、Nur Afiza Aziz、Chua Hui Shan、Zalina Ismail、Lailatul Akmar Mat Nor、Marlindawati Mohd Ali、Nur Hanani Ahmad、Mohammad Noor Amal Azmai、Syafinaz Amin-Nordin

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Department of Biomedical Sciences,Faculty of Medicine and Health Sciences,Universiti Putra Malaysia,43400 Serdang,Selangor,Malaysia

School of Biology,Faculty of Applied Sciences,Universiti Teknologi MARA,Negeri Sembilan,72000 Kuala Pilah,Malaysia

Department of Oral Biology&Biomedical Sciences,Faculty of Dentistry,MAHSA University,42610 Jenjarom,Selangor,Malaysia

School of Bioscience,Faculty of Pharmacy and Biomedical Sciences,MAHSA University,42610 Jenjarom,Selangor,Malaysia

Department of Pathology,Sultanah Aminah Hospital,80100 Johor Bahru,Johor,Malaysia

Department of Pathology,Melaka General Hospital,75400 Melaka,Malaysia

Department of Medical Microbiology and Immunology,Faculty of Medicine,Universiti Kebangsaan Malaysia,56000 Cheras,Kuala Lumpur,Malaysia

Department of Pathology,Sultan Idris Shah Serdang Hospital,43000 Kajang,Selangor,Malaysia

Department of Pathology,Tuanku Ja'afar Hospital,70300 Seremban,Negeri Sembilan,Malaysia

Department of Pathology,Sungai Buloh Hospital,47000 Sungai Buloh,Selangor,Malaysia

Department of Biology,Faculty of Science,Universiti Putra Malaysia,43400 Serdang,Selangor,Malaysia

Aquatic Animal Health and Therapeutics Laboratory,Institute of Bioscience,Universiti Putra Malaysia,43400 Serdang,Selangor,Malaysia

Department of Medical Microbiology,Faculty of Medicine and Health Sciences,Universiti Putra Malaysia,43400 Serdang,Selangor,Malaysia

Department of Medical Microbiology,Sultan Abdul Aziz Shah Hospital,Universiti Putra Malaysia,Persiaran MARDI-UPM,43400,Selangor,Malaysia

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Research Grants from Universiti Putra MalaysiaMinistry of Higher Education under the Fundamental Research Grant Scheme

UPM/800-3/3/1/GPB/2020/9683800FRGS/1/2023/WAB04/UPM/01/4

2024

10.4103/apjtm.apjtm_965_23

亚太热带医药杂志(英文版)

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年,卷(期)：2024.17(9)