首页|AGTR1 A1166C gene polymorphism is associated with the effectiveness of valsartan monotherapy in Chinese patients with essential hypertension:A retrospective analysis
AGTR1 A1166C gene polymorphism is associated with the effectiveness of valsartan monotherapy in Chinese patients with essential hypertension:A retrospective analysis
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Objective:To investigate whether angiotensin Ⅱ type 1 receptor(AGTR1 A1166C)gene polymorphism was associated with the effectiveness of valsartan monotherapy in Chinese patients with essential hypertension.Methods:This retrospective analysis included 198 patients(≥18 years of age)who received valsartan monotherapy(80 mg/day)for newly developed essential hypertension at the authors'center between January 1,2020 and December 31,2023.Genotyping for AGTR1 A1166C gene polymorphism was done by polymerase chain reaction(PCR)-melting curve analysis of genomic DNA from peripheral blood samples.A dominant genetic model for AGTR1 A1166C(AA genotype versus AC+CC genotype)was used.Multivariate regression analysis of baseline variables and AGTR1 polymorphism was conducted to identify predictors of target blood pressure attainment(<140/90 mmHg)at the 4-week follow-up.Results:The median age of the 198 patients was(53.7±13.5)years,and 58%were men.Genotyping assays showed that 164 patients had the AA genotype,and 34 patients were of the AC/CC genotype,including 30 with the AC genotype and 4 with the CC genotype.Allele distribution was consistent with Hardy Weinberg equilibrium.109 Patients(55.1%)attained the blood pressure target.Multivariate analysis showed that smoking(versus no smoking,HR 0.314,95%CI 0.159-0.619,P=0.001)and AGTR1 A1166C AA genotype(versus AC/CC,HR 2.927,95%CI 1.296-6.611,P=0.023)were significant and independent predictors of target attainment.25 Patients(73.5%)with AGTR1 A1166C AC/CC genotype attained the target versus 51.2%(51/164)of patients with AGTR1 A1166C AA genotype(P=0.017).Patients with AGTR1 A1166C AC/CC genotype had a significantly greater reduction in systolic blood pressure[(33.1±10.8)mmHg versus(29.2±11.7)mmHg in AA carriers;P=0.029)].Conclusions:Hypertensive patients carrying one or two C alleles of the AGTR1 A1166C gene were more responsive to valsartan treatment.
Essential hypertensionAngiotensin Ⅱ type 1 receptor antagonistValsartanAGTR1 A1166CGene polymorphism
Hanzhong Yu、Lei Li、Shuyao Wei、Qianqian Kong、Wei Nu、Bo Dong、Yuewu Zhao、Li Wang
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Department of Clinical Laboratory,the Affiliated Xuzhou Municipal Hospital of Xuzhou Medical University,Xuzhou,Jiangsu 221116,China
Department of Clinical Laboratory,Xuzhou Tumor Hospital,Xuzhou,Jiangsu 221005,China
Department of Cardiovascular Medicine,the Affiliated Xuzhou Municipal Hospital of Xuzhou Medical University,Xuzhou,Jiangsu 221116,China
Science and Technology Key Project of Xuzhou Municipal Health Commission,Jiangsu Province,ChinaPengcheng Yingcai-Medical Young Reserve Talent Programme
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