Orbital Extranodal Marginal Zone Lymphoma of Mucosa-Associated Lymphoid Tissue:A Clinicopathologic Study of 24 Cases
Objective:To explore the clinicopathological characteristics,differential diagnoses,pathogenesis,and treatment strategies of orbital extranodal marginal zone lymphoma of mucosa-associated lymphoid tissue(MALT lymphoma)to enhance understanding and provide clinical reference.Methods:We retrospectively analyzed the clinical data,pathological features,and immunohistochemistry findings of patients diagnosed with orbital extranodal marginal zone MALT lymphoma between 2021-2024,and reviewed the related literature.Results:A total of 24 cases were analyzed,with only one case of relapse.The male-to-female ratio was 2∶1,with the median age was 58 years.Among the cases,14 were located in the left orbit and 10 in the right orbit,all being unilateral.Various clinical features were observed,with all cases presenting a palpable mass.Additional symptoms included exophthalmos in 7 cases,erythema in 2 cases,epiphora in 2 cases,and eyelid edema in 1 case.Pathologically,the tumors were soft with poorly defined boundaries,and all were diagnosed as orbital MALT lymphoma.19 cases had diffuse growth pattern and 5 cases had a nodular growth pattern.The neoplastic cells exhibited abundant clear cytoplasm with a monocytoid appearance,with 2 cases showing plasmacytoid differentiation.All cases expressed B cell antigens and demonstrated a low Ki67 level(5％-15％).Conclusion:Orbital MALT lymphoma was the most common indolent lymphoma affecting the orbit,mainly observed in elderly individuals.Diagnosis primarily relied on a combination of imaging,pathology and immunohistochemistry.
pathologyorbital extranodal marginal zone lymphoma of mucosa-associated lymphoid tissueclinical and pathological featureliterature review
NETL
NSTL
万方数据
