Analysis of Traditional Chinese Medicine Syndromes Characteristics and Influencing Factors of Refractory Gout
Objective:To explore the influencing factors and Chinese medicine evidence characteristics of refractory gout(RG),and to provide a reliable clinical basis for the prevention and treatment of refractory gout.Methods:Clinical data of 199 gout patients attending the nephrology endocrine clinic and gout(GA)clinic of Tongzhou district,Dongzhimen Hospital Beijing University of Chinese Medicine were collected from January 2021 to June 2022,which were classified into 46 cases of RG patients and 153 cases of non-RG patients,to analyze the characteristics of Chinese medicine syn-dromes and the pathogenic influences in the RG patients.Results:Intergroup comparisons of the proportion of Yang de-ficiency,Qi stagnation,damp-heat,phlegm-dampness,and blood deficiency symptoms in the two groups were not statis-tically significant(P＞0.05);the proportion of Qi deficiency symptoms,Yin deficiency symptoms,and blood stasis symptoms in the patients of the refractory gout group was higher,and compared with that of the non-refractory gout group,the difference was statistically significant(P＜0.05).The differences between the two groups were not statisti-cally significant in gender distribution,percentage of diabetes mellitus and hyperlipidemia,and between-group compari-sons of LDL,total cholesterol,and triglycerides(P＞0.05);RG patients had a higher percentage of hypertension and cerebral infarction,and their age,blood creatinine,blood uric acid,and urea were significantly higher than those in the non-RG group,whereas HDL was significantly lower than those in the non-RG group,and the differences were statisti-cally significant(P＜0.05).Univariate binary logistic regression analysis suggested that the presence of hypertension,cerebral infarction,the presence of blood stasis evidence,yin deficiency evidence,as well as age,blood creatinine,urea,blood uric acid,and high-density lipoprotein were the influencing factors of RG;and multifactorial binary logistic regres-sion analysis suggested that the presence of yin deficiency evidence,the presence of blood stasis evidence,the presence of hypertension,and blood uric acid were the independent risk factors of RG.Conclusion:Patients with RG were older and had more comorbidities,Yin deficiency and blood stasis were the key pathogenetic factors in the development of RG,and a history of hypertension and higher blood uric acid levels were also closely associated with the development of RG.
Refractory GoutTraditional Chinese Medicine EvidenceComorbiditiesInfluencing Factors
NETL
NSTL
万方数据
