目的:利用R语言数据挖掘技术分析脓毒症的中医证型及用药规律，为脓毒症临床中医诊疗方案提供参考。方法:通过检索PubMed、Web of Science、中国知网、万方、维普和中国生物医学文献数据库，收集从建库至2023年12月31日收录的符合纳入标准的中医药治疗脓毒症临床研究文献，建立相关处方数据库。运用Excel整理并分析方药信息，包括中医辨证分型、治法治则，中药的使用频次、性味、归经、功效等;并利用R语言进行关联规则分析及聚类分析。结果:共检索出文献10 345篇，纳入分析280篇，涉及中药215味，其中排名前10的中药分别是大黄、甘草、赤芍、厚朴、黄芪、芒硝、黄芩、丹参、地黄、枳实;四气以寒、温为主，五味以苦、甘、辛为主，归经以脾、胃、肺为主，功效以清热、补虚、泻下为主，证型以热毒内盛证、瘀毒内阻证为主。关联规则分析得到核心组方为大黄、芒硝、枳实、厚朴、当归、川芎、赤芍、桃仁、地黄、红花。高频药物聚类分析得到4个聚类群，适用于不同证型。结论:治疗脓毒症的用药规律以清热、泻下、化瘀、补虚为主，核心证型—处方有4类，临床上应根据患者的证候特点进行辨证论治，在核心证型—处方的基础上随证加减。
Analysis of Syndrome Type and Medication Rules of Traditional Chinese Medicine in Patients with Sepsis Based on Data Mining with R Language
Objective:To analyze the syndrome type and medication rules of traditional Chinese medicine(TCM)in pa-tients with sepsis based on R language data mining technology,so as to provide reference for clinical TCM diagnosis and treatment for sepsis.Methods:Clinical research literatures on TCM treatment for sepsis which met the inclusion crite-ria were established relevant prescription databases by searching PubMed,Web of Science,CNKI,WanFang,VIP,and the Chinese biomedical literature database until December 31,2023.The prescription information including TCM syn-drome differentiation and treatment principles,frequency of use as well as the nature,taste,and meridian of Chinese herbal,were all organized and analyzed by using Excel.Association rule analysis and cluster analysis were also conduc-ted by using R language.Results:A total of 10 345 literatures were retrieved and 280 were included in the analysis,in-volving 215 Chinese herbal.Among them,the top ten Chinese herbal were Rhei Radix et Rhizoma(Da Huang),Gly-cyrrhizae Radix et Rhizoma(Gan Cao),Paeoniae Radix Rubra(Chi Shao),Magnoliae Officinalis Cortex(Hou Po),Astragali Radix(Huang Qi),Natrii Sulfas(Mang Xiao),Scutellariae Radix(Huang Qin),Salviae Miltiorrhizae Ra-dix et Rhizoma(Dan Shen),Rehmanniae Radix(Di Huang),Aurantii Fructus Immaturus(Zhi Shi).The four proper-ties was mainly cold and warm,and the taste of medicine was bitter,sweet and pungent.Meridian tropism was mostly found in spleen,stomach,and lungs,and the efficacy was mainly in clearing heat,tonifying deficiency,and diarrhea effect.Whatsmore,the syndrome types were mainly characterized by Internal Excessive Heat and Toxin Syndrome and Stasis and Toxin Internal Obstruction Syndrome.The core formulas obtained through association rule analysis were Rhei Radix et Rhizoma(Da Huang),Natrii Sul fas(Mang Xiao),Aurant ii Fructus Immaturus(Zhi Shi),Magnoliae Officinalis Cortex(Hou Po),Angelicae Sinensis Radix(Dang Gui),Ghuanxiong Rhizoma(Chuan Xiong),Paeoniae Radix Rubra(Chi Shao),Persicae Semen(Tao Ren),Rehmanniae Radix(Di Huang),Carthami Flos(Hong Hua).High frequency drug clustering analysis resulted in four clusters,which were suitable for different syndrome types.Conclu-sion:The medication rules for the treatment of sepsis are mainly clearing heat,removing blood stasis,and tonifying deficiency.There are four types of core syndrome-prescription.The dialectical treatment can be carried out based on the characteristics of the patient's syndrome,and adjustments can be made according to the syndrome on the basis of the core syndrome-prescription in clinical practice.
SepsisData MiningR LanguageTraditional Chinese MedicineSyndrome TypeMedication Rules
万方数据
维普
