Prevention and Treatment of Traditional Chinese Medicine on Calcium Oxalate Kidney Stones Based on Nrf2 Signaling Pathway
Kidney stones are a condition characterized by the abnormal accumulation of crystalline substances such as calcium and oxalates within the kidney.The pathogenesis of kidney stones is intricate,encompassing various biological processes like oxidative stress and inflammation.Traditional Chinese medicine has demonstrated significant efficacy in preventing and treating kidney stones,leveraging advantages such as multiple targets,diverse components,and path-ways.Research indicates that the nuclear factor erythroid 2-related factor 2(Nrf2)signaling pathway and its down-stream factors are one of the important pathways in the prevention and treatment of kidney stones.Based on this,this article summarizes the latest progress in the prevention and treatment of calcium oxalate kidney stones using traditional Chinese medicine formulations and monomer components.Research has found that traditional Chinese medicine can ef-fectively prevent and treat kidney stones by activating the Nrf2 signaling pathway,reducing oxidative stress and inflam-mation levels,regulating cell autophagy and apoptosis,and inhibiting ferroptosis.However,current research on com-pound formulas with traditional Chinese medicine characteristics in the prevention and treatment of kidney stones is still insufficient.Future research should focus on exploring the potential mechanisms of traditional Chinese medicine formu-lations prevent and treat kidney stones,in order to provide more treatment options and insights for the treatment of cal-cium oxalate kidney stones.
Kidney StonesCalcium OxalateNuclear Factor Erythroid 2-Related Factor 2(Nrf2)Traditional Chinese Medicine
万方数据
维普
