Testicular and epididymal coefficients,histological morphology,sperm motility and fertility of wild-type and AKR7A5 knockout male mice are analyzed to investigate the effects of AKR7A5 gene on the male mouse repro-duction.The results show that there are no significant difference in testicular and epididymal coefficients and histo-logical morphology between AKR7A5 knockout and wild-type mice.Compared to wild-type mice,the sperm concen-tration,total number of straight linear motility,progressive motility sperm,progressive sperm,average path motile speed and average curve motile speed of AKR7A5 knockout mice decrease significantly(P＜0.01),while the im-motile sperm increases significantly(P＜0.01).The total litter size of offspring decreases significantly(P＜0.01).In conclusion,AKR7A5 gene knockout affects the number and motility of mature sperm and reduces the to-tal litter size of mice.
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