Gel Transformation and Degradation Process of Sodium Alginate in Simulated Body Fluid Environment
To explore the gel transition and degradation characteristics of alginate in the human body,a systematic study was conducted on the gelation and degradation processes of sodium alginate(SA)under a simulated body flu-id environment.For the gelation process,the influence of gel formation conditions,as well as the viscosity,mass concentration,and volume ratio of sodium alginate,were investigated.Regarding the degradation process,the effects of SA viscosity,mass concentration,and calcification time were explored.The experimental results show that in the simulated body fluid environment,the gel formation rate increased almost linearly,and the generated gel block exhibited uniform texture.At the 16 h mark,as the viscosity increased(from 49 mPa·s to 456 mPa·s),the gel formation rate rose from 85.5%to 100%.Meanwhile,as the solution mass concentration increased(from 3 mg/mL to 20 mg/mL),the time required to reach 100%gel formation increased from 16 to 24 h.There was no significant difference in the degradation pattern between gels formed with viscosities of 112 mPa·s and 196 mPa·s,but the difference lay in the strength of the initially formed gel structure.Therefore,the appropriate viscosity can be selected based on the gel strength required at the injection site.The gel degradation rate was strongly correlated with the SA mass concentration:higher concentrations lead to slower degradation.Compared to sodium alginate gel(GSA-112),oxidized sodium alginate gel(GOSA-5)degraded faster with GOSA-5 fully degrading within 15 days,while GSA-112 required 25 days to achieve complete degradation.Therefore,the degradation time of implanted gels in vivo can be controlled by adjusting SA viscosity,mass concentration and oxidative modification.
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