首页|Engineering of ovarian tissue for ovarian dysfunctions:A review

Engineering of ovarian tissue for ovarian dysfunctions:A review

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This review explores tissue engineering as a potential solution for reproductive health issues in women caused by genetic or acquired diseases,such as premature ovarian failure or oophorectomy.The loss of ovarian function can lead to infertility,osteoporosis,and cardiovascular disease.Hormone replacement therapy is a common treatment,but it has limitations and risks.The review focuses on two main approaches in tissue engineering:scaffold-based(3D printing,electrospinning,decellularization)and scaffold-free(stem cell transplantation,organoid cultivation).Both approaches show promise in preclinical studies for creating functional ovarian tissue.Challenges include vascularization,innervation,long-term function,and safety.Despite these challenges,tissue engineering offers a potential avenue for restoring fertility and hormone balance in women with ovarian dysfunction.

Female gonadsTissue engineeringEstrogenReproductive system

Aliya Zhylkybekova、Gulbakit K.Koshmaganbetova、Myltykbay S.Rysmakhanov、Nurgul Abdullayevna Abenova、Nadiar Maratovich Mussin、Asset Askerovich Kaliyev、Mahdi Mahdipour、Amin Tamadon

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Department of Evidence-Based Medicine and Scientific Management,West Kazakhstan Marat Ospanov Medical University,Aktobe,Kazakhstan

Department of Surgery and Urology No.2,West Kazakhstan Medical University,Aktobe,Kazakhstan

Department of Surgery and Transplantation,Aktobe Medical Center,Aktobe,Kazakhstan

Department of Internal Diseases,West Kazakhstan Marat Ospanov Medical University,Aktobe,Kazakhstan

Stem Cell Research Center,Tabriz University of Medical Sciences,Tabriz,Iran

Department of Reproductive Biology,Faculty of Advanced Medical Sciences,Tabriz University of Medical Sciences,Tabriz,Iran

Department for Scientific Work,West-Kazakhstan Marat Ospanov Medical University,Aktobe,Kazakhstan

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2024

10.4103/apjr.apjr_81_23

亚太生殖杂志(英文版)

亚太生殖杂志(英文版)

ISSN：
年,卷(期)：2024.13(1)
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