首页|Protective effect of co-enzyme Q10 on testicular tissue and sperm parameters in adult male rats treated with Sunset Yellow FCF

Protective effect of co-enzyme Q10 on testicular tissue and sperm parameters in adult male rats treated with Sunset Yellow FCF

扫码查看
原文链接
  • NETL
  • NSTL
  • 万方数据
Objective:To determine the protective effect of co-enzyme Q10(CoQ10)on testicular tissue and sperm parameters in male rats treated with Sunset Yellow FCF.Methods:Sixty male Sprague-Dawley rats were randomly divided into 6 groups of the control,CoQ10(10 mg/kg/day),low dose of Sunset Yellow(2.5 mg/kg),high dose of Sunset Yellow(70 mg/kg),low dose of Sunset Yellow(2.5 mg/kg)plus CoQ10,and high dose of Sunset Yellow(70 mg/kg)plus CoQ10.The drugs were administered via daily oral gavages for 6 weeks.At the end of the experiment,sperm analysis,stereological and histological assessments of the testis were carried out.Results:The normal morphology(by 41.1%)and progressive spermatozoa(by 74.8%),testicle volume(by 33.4%),lumen volume(by 38.3%),interstitial tissue volume(by 44.7%),seminiferous tubule volume(by 40.7%),and number of spermatogonia(by 53.9%)and Leydig cells(by 70.7%)reduced in the rats that received high doses of Sunset Yellow in comparison to the control group.Nonetheless,all these alterations were recovered by CoQ10 treatment in the CoQ10 plus high dose of Sunset Yellow group.Furthermore,low doses of Sunset Yellow did not affect different parameters of the testis and sperm.Conclusions:CoQ10 could,to some extent,prevent structural changes of the testis induced by the high dose of Sunset Yellow.

Sunset Yellow FCFCo-enzyme Q10TesticleSpermStereology

Rohollah Nazari、Somayeh Akbari、Maryam Naseh、Shayan Yousufzai、Seyede Fatemeh Hosseini、Fatemeh Karimi

展开 >

Histomorphometry and Stereology Research Center,Shiraz University of Medical Sciences,Shiraz,Iran

Anatomy Department,School of Medicine,Shiraz University of Medical Sciences,Shiraz,Iran

Student Research Committee,Medical School,Shiraz University of Medical Sciences,Shiraz,Iran

Faculty of Tabas,School of Nursing,Birjand University of Medical Sciences,Birjand,Iran

展开 >

Histomorphometry and Stereology Research Center from Shiraz University of Medical Sciences

94-7624

2024

10.4103/apjr.apjr_55_23

亚太生殖杂志(英文版)

亚太生殖杂志(英文版)

ISSN：
年,卷(期)：2024.13(2)
  • 28