Improvement study on the identification test of vacant gelatin capsules and enterosoluble vacant gelatin capsules
Objective:To compare the differences in identification tests of vacant gelatin capsules and enterosolu-ble vacant gelatin capsules in the four national pharmacopoeias,optimize the identification test methods and improve the specificity of identification results.Methods:The biuret method was used to identify vacant gelatin capsules and enterosoluble vacant gelatin capsules,and an appropriate amount of adsorbed activated carbon was added to eliminate the masking effect of pigments in capsules.Results:The identification method was optimized,the pigment in the capsule solution was adsorbed by activated carbon,and the capsule solution showed a clarified colorless solution,which could produce a distinct violet after the color development by biuret reaction.Conclusion:This method can significantly improve the specificity of vacant gelatin capsules and enterosoluble vacant gelatin capsules identification compared with domestic and foreign pharmacopoeia methods.It can provide scientific and reasonable revision suggestions for the optimization and improvement of the identification test of va-cant gelatin capsules and enterosoluble vacant gelatin capsules in the Chinese Pharmacopoeia.
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