定量核磁共振氢谱检测右佐匹克隆片的含量
Determination of dexzopiclone tablets content by quantitative nuclear magnetic resonance
郑晓红 1车逸豪 2肖志会1
作者信息
- 1. 中国科学院南海海洋研究所仪器设备公共服务中心,广州 510301
- 2. 中国科学院南海海洋研究所中国科学院热带海洋生物资源与生态重点实验室,广州 510301
- 折叠
摘要
目的:建立定量核磁共振氢谱(qHNMR)测定右佐匹克隆含量的方法.方法:以1,3,5-三甲氧基苯δ 6.08处质子信号为内标峰,以右佐匹克隆δ 8.54、8.38、8.12、7.78处质子信号为定量峰,以DMSO-d6为溶剂,在恒温298 K,弛豫延迟时间10 s,扫描次数32次条件下采集氢谱.结果:定量核磁共振氢谱法测定右佐匹克隆片中右佐匹克隆平均含量为2.94％,即平均每片中含右佐匹克隆3.00 mg,RSD为0.15％,与药物说明标示的量基本一致.结论:定量核磁共振氢谱可用于药物中右佐匹克隆含量的测定,并且具有快速、准确以及操作简单等优势.
Abstract
Objective:To establish a quantitative 1H-NMR(qHNMR)method for the determination of dexzopi-clone tablets content.Methods:Proton signal at 8 6.08 of 1,3,5-trimethoxybenzene and 8 8.54,8.38,8.12,7.78 of dexzopiclone were served as the internal standard and quantitative peaks,respectively.DMSO-d6 was employed as the solvent.The qHNMR spectra were acquired at 298 K with 10 s relaxation delay and 32 scanning times.Results:The content of dexzopiclone was estimated to be 2.94％(RSD=0.15％)by qHNMR method,which indicated that 3.00 mg of dexzopiclone was in one tablet.The result was consistent with the description of the label.Conclusion:qHNMR method can be used to determine the content of dexzopiclone.The method is ac-curate,simple and efficient.
关键词
右佐匹克隆/1,3,5-三甲氧基苯/氢核磁共振定量法/含量测定Key words
dexzopiclone/quantitative nuclear magnetic resonance/content determination/1,3,5-trimethoxy-benzene引用本文复制引用
基金项目
中国科学院技术支撑人才项目(2021)(2022006)
出版年
2024
NETL
NSTL
万方数据