Determination of dexzopiclone tablets content by quantitative nuclear magnetic resonance
Objective:To establish a quantitative 1H-NMR(qHNMR)method for the determination of dexzopi-clone tablets content.Methods:Proton signal at 8 6.08 of 1,3,5-trimethoxybenzene and 8 8.54,8.38,8.12,7.78 of dexzopiclone were served as the internal standard and quantitative peaks,respectively.DMSO-d6 was employed as the solvent.The qHNMR spectra were acquired at 298 K with 10 s relaxation delay and 32 scanning times.Results:The content of dexzopiclone was estimated to be 2.94％(RSD=0.15％)by qHNMR method,which indicated that 3.00 mg of dexzopiclone was in one tablet.The result was consistent with the description of the label.Conclusion:qHNMR method can be used to determine the content of dexzopiclone.The method is ac-curate,simple and efficient.
dexzopiclonequantitative nuclear magnetic resonancecontent determination1,3,5-trimethoxy-benzene
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