Research of illicit drugs extraction technology based on electrospinning
Illicit drugs are widely distributed in complex substrates such as biology,food,environment and drugs at minor,trace and even ultra-trace levels,which may cause acute poisoning,chronic poisoning,drug abuse and other problems.The analysis of illicit drugs has always been the focus of public safety.Solid phase extraction is a commonly used pretreatment technology for the analysis of illicit drugs in complex substrates.However,when extracting trace level illicit drugs,problems such as low sample utilization rate and poor extraction sensitivity may occur,which are difficult to meet the needs of sensitive and rapid analysis in the field of public safety.To this end,nanofibers,nanoparticles and other materials with strong size advantages are used for optimization and innovation of solid phase extraction technology.Electrospinning technology is the most commonly used method for continuous and mass production of nanofibers.It has the advantages of simple process,diverse materials and con-trollable fiber size,and has been widely used in the field of analysis and extraction.The electrospinning technology has experienced the development from spinning with a single polymer to blending with a variety of polymers and modifying nanoparticles with functional materials.The mechanical properties,selectivity and stability of the electro-spinning nanofibers prepared have also been gradually improved,broadening the application scope of this technology in the analysis of illicit drugs.At present,the application of electrospinning technology in solid phase extraction of illicit drugs is still in its infancy.This paper systematically reviews the research status of electrospinning in tradition-al solid phase extraction,micro-solid phase extraction and dispersed solid phase extraction,and provides sugges-tions for its possible future development,in order to provide reference for further research on related issues.