Determination of 16 photoinitiator residuces in medicinal composite membranes with gas chromatography-mass spectrometry
Objective:To establish a gas chromatography-mass spectrometry(GC-MS)method for the determi-nation of 16 photoinitiator residuce levels in medicinal composite membranes,including benzophenone(BP)and 4-methylbenzophenone(4-MBP).Methods:The samples were extracted by ethylacetate,separated with TR-5MS column.The mass spectrum was analyzed with EI ionization,positive ion mode and selective reaction monitoring(SRM)mode and quantified with internal standard method.Results:The 16 kinds of photoinitiators had good linear relationships in the range of 0.05-2.0 μg·mL-1,and the correlation coefficients(r)were more than 0.997.The limits of detection(LODs)were 0.03 μg·mL-1.The average recoveries were(n=6)ranged from 81.3％to 94.0％,with RSDs of 2.1％-6.2％.The detection rate of 4-Isopropylthioxanthone(4-ITX)in the medicinal composite membranes was 30％,and the highest content was 0.02 μg·cm-2.Conclusion:The method is accurate with high sensitivity and simple pretreatment,which can be used for the detecting the kinds of photoinitiators in medicinal composite membranes.
gas chromatography-mass spectrometryphotoinitiatorsmedicinal composite membranesinternal standard methodresiduces
NETL
NSTL
万方数据
