首页|基于污水毒品监测技术的依托咪酯同系物筛查预警

基于污水毒品监测技术的依托咪酯同系物筛查预警

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  • NETL
  • NSTL
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目的:通过污水毒品监测技术进行新精神活性物质异丙咪酯(依托咪酯同系物)的预警,并开展定量研究,为列管及执法打击工作提供技术支撑.方法:通过在线固相萃取-超高效液相色谱-三重四极杆质谱联用(online solid phase extraction-ultra high performance liquid chromatography tandem mass spectrometry,Online-SPE-UPLC-MS/MS)的多反应监测模式(multiple reaction monitoring,MRM)定量分析获知异常结果,前体离子扫描模式定性确定异常物质基本信息,结合化合物定向合成后的超高效液相色谱-四极杆-静电场轨道阱高分辨质谱(ultra high performance liquid chromatography quadrupole-orbitrap high resolution mass spectrometry,UPLC-Q Exactive HRMS)平行反应监测(parallel reaction monitoring,PRM)模式进行定性确定,后购置市售对照品开展定量研究,并将所得结果运用SPSS 27进行相关性分析.结果:确定异常物质为异丙咪酯,并通过优化MRM参数可利用特定离子丰度比实现与其同分异构体的区分,定量结果相关性分析结果表明其与依托咪酯和氯胺酮滥用地区趋同.结论:在污水毒品监测过程中,需关注原型与代谢物的比例关系,总结归纳特定类型化合物的特征碎片及特征中性丢失信息,针对监测过程中的重点地区重点样本开展筛查性非靶向检测,结合高分辨质谱等手段进行潜在物质的分析,充分发挥污水毒品监测的预警作用.
Screening and early warning of etomidate homolog based on sewage drug monitoring technology
Objective:The early warning of new psychoactive substance iso-propoxate(homologue of etomid-ate)was carried out through sewage drug monitoring technology,and quantitative research was conducted to pro-vide technical support for management and law enforcement.Methods:The abnormal results were obtained by quantitative analysis of multiple reaction monitoring(MRM)mode using online solid phase extraction-ultra high performance liquid chromatography tandem mass spectrometry(SPE-UPLC-MS/MS),and the basic informa-tion of abnormal substance was determined by precursor ion scanning mode.The qualitative determination was car-ried out using parallel reaction monitoring(PRM)mode by ultra high performance liquid chromatography quadrupole-orbitrap high resolution mass spectrometry(UPLC-Q exactive HRMS)after the directional synthe-sis of the compound.Quantitative study was then conducted by commercial reference products.The correlation analysis was carried out by SPSS 27.Results:The abnormal substance was determined to be iso-propoxate.The optimized MRM parameters could be distinguished from its isomers by specific ion abundance ratio.The correlation analysis of quantitative results showed that it was similar to etomidate and ketamine abuse areas.Conclusion:In the process of sewage drug monitoring,it is necessary to pay attention to the proportional relation-ship between prototype and metabolite.It is important to summarize the characteristic fragments and characteristic neutral loss information of specific types of compounds,carry out screening non-targeted detection for key sam-ples in key areas in the monitoring process,and analyze potential substances using high-resolution mass spec-trometry and other methods,so as to fully leveraging the early warning role of sewage drug monitoring.

sewage drug monitoringnew psychoactive substancesiso-propoxatepropoxatedrug substitutesprecursor ion scanningetomidate homologUPLC-Q Exactive HRMS

韩兴、何美欣、李堪、杜明荦、刘昕、刘卫国

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广东省毒品实验技术中心国家毒品实验室广东分中心,广州 510230

污水毒品监测 新精神活性物质 异丙咪酯 丙咪酯 毒品替代物 前体离子扫描 依托咪酯同系物 超高效液相色谱-四极杆-静电场轨道阱高分辨质谱

公安部科技计划项目

2023JSM01

2024

10.16155/j.0254-1793.2024.06.16

药物分析杂志
中国药学会

药物分析杂志

CSTPCD北大核心
影响因子：1.039
ISSN：0254-1793
年,卷(期)：2024.44(6)