Objective:To explore the fragmentation patterns of synthetic cannabinoids by electron impact(EI)ionization mass spectrometry.Methods:Forty synthetic cannabinoids were systematically investigated by gas chro-matography coupled to mass spectrometry(GC-MS).Ionization mode was EI(70 eV)and the acquisition range was m/z 50-600.Results:According to the different structures of the"head group"and"linked group",forty synthetic cannabinoids were divided into six categories,namely cumyl-carboxamide type,adamantyl-carboxam-ide type,carbamoyl/methyl butyrate-carboxamide type,naphthylformyl type,benzoyl/phenylacetyl type and tetramethylcyclopropane-acyl type.Through the analysis of the mass spectrum of synthetic cannabinoids,the fragmentation pathways and characteristic ions of different types of synthetic cannabinoids were given.The main EI-MS fragmentation patterns of synthetic cannabinoids were that both sides of the carbonyl group in the"linking group"undergo α-cleavage,and the N atom on the indole/indazole parent nucleus was prone to γ-H rear-rangement,and loss of a R1.In addition,fragment ions m/z 116,130,144 and fragment ions m/z 117,131,145 were the characteristic fragments of indazole and indole parent nucleus,which could be used to identify the parent nucleus of synthetic cannabinoids.Conclusion:These kind of compounds have strong fragmentation regu-larity.When standard substances are lacking or commercial mass spectral libraries are difficult to obtain,the pro-posed synthetic cannabinoids EI-MS fragmentation pathways can help to rapidly identify the structures of un-known synthetic cannabinoids.
关键词
合成大麻素类/气相色谱-质谱/电子轰击模式/结构分类/裂解规律/特征碎片离子
Key words
synthetic cannabinoids/GC-MS/electron impact ionization tandem mass spectrometry/structural clas-sification/fragmentation patterns/characteristic fragmentation ion
维普
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