Effects of Microsphere TACE on the Treatment of Small Hepatocellular Carcinoma and Analysis of Relevant Factors
To study the effects of drug-loaded microspheres TACE on serum CXCL9 levels and short-term efficacy of primary small hepatocellular carcinoma and analysis of prognostic factors,a total of 110 patients with primary small liver cancer admitted to Cang-zhou third hospital from June 2016 to June 2020 were selected and divided into observation group and control group according to ran-dom number table method,with 55 cases in each group.All patients underwent radiofrequency ablation.Patients in the observation group received drug-loaded microsphere TACE,and patients in the control group received conventional iodized oil TACE.Quality of life,serum CXCL9,vascular endothelial growth factor and alpha fetoprotein,postoperative complications,long-term clinical efficacy were compared between the two groups.They were followed up to September 2021,univariate and multivariate analysis of postopera-tive survival of patients with small liver cancer,to determine the independent factors affecting the prognosis of patients.After treat-ment,the observed group exhibited significantly lower scores in quality of life compared to the control group.Serum concentrations of CXCL9,VEGF,and AFP in the observed group were markedly lower than those in the control group.During the treatment period,both groups experienced complications such as nausea,vomiting,leukopenia,thrombocytopenia,anemia,renal toxicity,fever,organ damage,and diaphragmatic injury,but no significant differences were observed.The median disease-free survival time of patients in the observation group was 25.9 months,which was significantly higher than the 21.9 months in the control group,and the difference was statistically significant(x2=0.431,P=0.019).Univariate analysis results indicated that the median disease-free survival in small hepatocellular carcinoma was correlated with age,coronary heart disease,hypertension,cirrhosis,ascites,smoking history,intra-operative blood transfusion volume,tumor number,encapsulation integrity,portal vein tumor thrombus,treatment modality,and indica-tors such as CXCL9,VEGF,and AFP(P＜0.05).Cox regression analysis revealed that intraoperative bleeding volume,tumor num-ber,portal vein tumor thrombus,incomplete encapsulation,treatment modality,and CXCL9 were independent prognostic factors affec-ting patient outcomes(P＜0.05).Drug-loaded microspheres TACE combined with sequential microwave ablation can effectively improve the quality of life and reduce the levels of Serum CXCL9,VEGF and AFP,which is safe and effective.Intraoperative blood loss,tumor number,portal vein tumor thrombin,incomplete capsule,treatment method and serum CXCL9 are independent influencing factors for the recurrence of primary small liver cancer,worthy of further clinical research and promotion.
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