Effect of Xipayi Gum Fixing Liquid Combined with Minocycline on Moderate and Severe Chronic Periodontitis and its Influence on Inflam-matory Factors
To analyze the effect of Xipayi gingival fixative solution combined with minocycline in the treatment of moderate to severe chronic periodontitis and its influence on inflammatory factors,80 patients with moderate and severe chronic periodontitis from May 2020 to July 2021 were selected and divided into the combined group and the control group with 40 patients in each group according to different treatment methods.On the basis of routine treatment,the combined group was treated with Xipayi Gum Fixing Solution and minocycline,while the control group was treated with minocycline only,all of which were treated continuously for 4 weeks.After treatment,the effects of the two groups were compared,and then the periodontal indicators[bleeding index(BI),plaque index(PLI),periodontal pocket depth(PD),attachment loss(AL)],gingival crevicular fluid inflammatory factor,tumor necrosis factor-α(TNF-α)、Interleukin-1β(IL-1β)、Interleukin-6(IL-6)]level and masticatory function(biting force and masticatory efficiency),as well as adverse reactions during treatment.The effective rate of combination group was 95.00％higher than that of control group(77.50％)(P＜0.05).After treatment,PI,SBI,PD and AL in two groups were significantly lower than those before treatment,and those in combined group were lower than those in control group(P＜0.01).Levels of TNF-α、IL-1β and IL-6 in combined group were lower than those in control group after treatment(P＜0.01).After treatment,the bite force and masticatory efficiency of two groups were higher than those before treatment,and those of combined group were higher than those of control group(P＜0.01).Xipayi Gum Fixing Liquid combined with minocycline can effectively improve the periodontal indicators of patients with moderate to severe chronic periodontitis,alleviate inflammation,improve efficacy,improve masticatory function,and have fewer adverse reactions.
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