Preliminary Study of Elevated Serum CA72-4 Caused by Oral Colchicine
To explore the cause of increased serum CA72-4 induced by oral colchicine,combined with the cases of elevated serum CA72-4 in non-tumor patients,the effect of colchicine on the secretion of CA72-4 in gastric cancer cell line BGC-823 was investiga-ted by cell experiment.The co-treatment of colchicine and serum in vitro was used to determine whether colchicine directly interfered with the detection of serum CA72-4.After the treatment of gastric cancer cell BGC-823 with different concentrations of colchicine for 24 hours,there was no statistically significant difference in the concentrations of CA72-4 in the cell supernatant of each group.While colchicine and patient's serum were co-treated in vitro for 1,2 and 3 hours,there was no statistically significant difference in the concentration of serum CA72-4 in each group.CA72-4 is one of the tumor markers indicating gastric cancer,but the mechanism of CA72-4 production in gastric cancer cells is not completely clear,and the mechanism of the increase of CA72-4 caused by colchicine is not fully clarified.Clinicians and clinical pathologists should consider the possible changes in serum CA72-4 concentration caused by drug factors.
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