Expression and Clinical Significance of SPP1 and PI3K in Cervical Cancer Cells
This study aims to investigate the expression levels of SPP1 and PI3K in cervical cancer cells and their association with clinical pathological features,further elucidating their potential roles in the development of cervical cancer.By including cancer tissue and adjacent normal tissue samples from 120 cervical cancer patients treated at the hospital,the authors analyzed the expression levels of SPP1 and PI3K in the enrolled patients'cancer tissue and adjacent normal tissue using immunohistochemistry.Pearson cor-relation analysis was conducted to examine the relationship between the expression of SPP1 and PI3K in cancer tissue and adjacent normal tissue and clinical pathological features,such as staging and lymph node metastasis in the enrolled patients,as well as the cor-relation between the expression of SPP1 and PI3K.In cervical cancer tissue,SPP1 expression was significantly upregulated,charac-terized by intense staining,primarily located in the cancer cell membrane and cytoplasm,and markedly increased compared to adja-cent normal tissue.The expression level of PI3K in cancer tissue was also significantly elevated,displaying strong staining,predomi-nantly found in the cancer cell cytoplasm,and exhibited a notable difference compared to adjacent normal tissue.Statistical analysis revealed that the positivity rates of SPP1 and PI3K expression were not statistically significant with regard to the age and tumor size differences in cervical cancer patients but were statistically significant with clinical staging and lymph node metastasis.Pearson corre-lation analysis indicated a positive correlation between high expression of SPP1 and PI3K with clinical staging and lymph node metas-tasis in cervical cancer patients.Additionally,there was a positive correlation between the expression of SPP1 and PI3K.This study discovered that SPP1 and P13K play a pivotal role in the development of cervical cancer,with their high expression closely associated with tumor progression and metastasis.These findings provide new insights for the treatment and prognosis assessment of cervical cancer and offer a potential foundation for the development of therapeutic strategies targeting SPP1 and PI3K.Further research is needed to explore their precise regulatory mechanisms and interactions with other signaling pathways.
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