Effect of Vonoprazan in the Treatment of Helicobacter Pylori
To observe the effect and safety of vonoprazan(VNP)in the treatment of Helicobacter pylori(Hp),240 patients with chro-nic gastritis and Hp infection were enrolled.According to random number table method,they were divided into proton pump inhibitors(PPI)14 d group,VNP 14 d group and VNP 7 d group,80 cases in each group.PPI 14 d group was treated with rabeprazole 20 mg bid+colloidal bismuth pectin granules 200 mg bid+amoxicillin capsules 1 000 mg bid+clarithromycin tablets 500 mg bid for 14 d,VNP 7 d group was treated with vonoprazan fumarate tablet 20 mg bid+amoxicillin capsules 1 000 mg bid for 7 d,and VNP 14 d group was treated with vonoprazan fumarate tablet 20 mg bid+amoxicillin capsules 1 000 mg bid for 14 d.At 4～6 w after drug withdrawal,fasting 13C-urea breath test was performed to re-examine Hp.The eradication rate of Hp and incidence of adverse reac-tions were compared among the three groups.There were 76 patients,77 patients and 74 patients completed the treatment in PPI group 14 d,VNP 14 d group,and VNP 7 d group,respectively.According to intention to treat(ITT)analysis,eradication rates of Hp in PPI 14 d group,VNP 14 d group and VNP 7 d group were 80.0％,83.8％,and 76.3％,respectively.According to per protocol(PP)analysis,eradication rates of Hp in the three groups were 84.2％,87.0％and 82.4％,respectively.There was no significant difference in eradication rate of Hp among the three groups(x2ITT analysis=1.41,x2PP analysis=0.62,P＞0.05).All adverse events were mild in the three groups,and there was no significant difference in the incidence of adverse reactions among the three groups(8.8％,11.3％,8.8％;P＞0.05).VNP 7 d has good tolerance,and its curative effect and safety are similar to those of PPI 14 d and VNP 14 d,which may be one of the recommended regimens for Hp eradication.
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