Application and Research Progress of Berberine in Regulating Bcl-2/Bax Signaling Pathway to Induce Cell Apoptosis
Berberine is a natural active ingredient mainly extracted from rhizome of Coptis.It interacts with many intracellular targets and has a wide range of pharmacological activities such as antioxidant,anti-inflammatory and antibacterial.As an important cell death mode,apoptosis plays an important role in organism development,immune system regulation,tumor suppression and tissue repair.Previous studies have preliminarily confirmed that berberine can play a role in the treatment of nervous system,cardiovascular sys-tem,digestive system,immune system and other related diseases by regulating apoptosis.It mainly affects the expression of apoptosis-related proteins and the transduction of signaling pathways,especially the Bcl-2/Bax signaling pathway.Bcl-2/Bax,as an important regulator of apoptosis pathway,plays an important role in the occurrence and development of neurological,cardiovascular,digestive and immune system diseases.However,the mechanism of how berberine regulates apoptosis in these diseases remains to be further studied.Relevant studies have confirmed that berberine can regulate the apoptosis induced by Bcl-2/Bax signaling pathway and play a protective role in nervous system in Alzheimer's disease,Parkinson's disease,Huntington's disease and other diseases.It can regu-late the apoptosis induced by Bcl-2/Bax signaling pathway in doxorubicin or hypoxia-induced heart injury,myocardial ischemia/reperfusion injury,and heart failure after myocardial infarction,and play a protective role in the cardiovascular system.It can regulate the apoptosis induced by Bcl-2/Bax signaling pathway in Helicobacter pylori induced gastric injury,chronic atrophic gastritis,sepsis complicated with intestinal injury and radiation enteritis,and play a protective role in the gastrointestinal system.It can regulate cell apoptosis induced by Bcl-2/Bax signaling pathway in rheumatoid arthritis,colorectal cancer,cervical cancer,and triple-negative breast cancer,and play a protective role in the immune system.In this paper,the mechanism of berberine mediated apoptosis was sys-tematically reviewed from the perspective of Bcl-2/Bax signaling pathway,in order to provide scientific basis for the application of berberine in the clinical treatment of diseases.
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