细胞外囊泡在创面愈合中的应用进展
Progress in the Application of Extracellular Vesicles in Wound Healing
陈宏伟1
作者信息
- 1. 淮安市中医院脑外科,江苏淮安 223100
- 折叠
摘要
创面愈合是指机体因遭受外力的作用,皮肤等组织出现离断或缺损后的愈复过程.若创面愈合不良或创面无法及时愈合遗留病理性瘢痕,易对患者产生多方面的影响,因此迫切需要找到一种更有效的方法来促进创面的愈合.细胞外囊泡,尤其是外泌体,除介导细胞间相互进行信息交流外,还是促进伤口愈合的重要分泌产物,其主要通过在细胞之间运输各种分子DNA、RNA和蛋白等发挥作用.相关研究表明外泌体可通过调节炎症反应、促进细胞增殖和迁移、促进血管生成、抑制瘢痕生成等多种途径改善伤口愈合,这将为临床治疗提供新的思路和方法,故本研究对外泌体在创面愈合中的应用进展进行综述.
Abstract
Wound healing refers to the healing process after the body is subjected to external force and the skin and other tissues are severed or defective.If the wound healing is poor or the wound cannot heal in time,the remaining pathological scars are easy to affect patients in many ways,so it is urgent to find a more effective way to promote the healing of the wound.Extracellular vesicles,espe-cially exosomes,in addition to mediating information exchange between cells,are also important secretory products to promote wound healing.It mainly works by transporting various molecules such as DNA,RNA and proteins between cells.Relevant studies have shown that exosomes can promote wound healing by regulating inflammatory response,promoting cell proliferation and migration,angiogenesis,inhibiting scar formation and other ways,which will provide new ideas and methods for clinical treatment.Therefore,the application of exosomes in wound healing was reviewed in this study.
关键词
细胞外囊泡/间充质干细胞/外泌体/创面愈合Key words
Extracellular vesicles/Mesenchymal stem cell/Exosomes/Wound healing引用本文复制引用
出版年
2024
NETL
NSTL
万方数据