The Effect of Ceftriaxone Sodium Combined with Penicillin on Coagula-tion Function,Maternal and Infant Outcomes,Erythrocyte Sedimentation Rate,C-reactive Protein,and PCT Levels in Patients with GBS Infection in Late Pregnancy
To investigate the effects of ceftriaxone sodium combined with penicillin on coagulation function,maternal and infant out-comes,erythrocyte sedimentation rate(ESR),C-reactive protein(CRP),and procalcitonin(PCT)levels in patients with group B Streptococcus(GBS)infection in late pregnancy,a total of 106 patients with GBS infection in the third trimester of pregnancy from December 2020 to December 2022 were selected and randomly divided into study group(n=53)and control group(n=53)using a random number table method.The control group was treated with penicillin,while the study group was treated with ceftriaxone sodium in addition to the control group.The adverse outcomes,adverse reactions,and coagulation function indicators[activated par-tial thromboplastin time(APTT),prothrombin time(PT),international normalized ratio(INR),fibrinogen(FIB)],ESR,CRP,PCT levels,and ESR were compared between the two groups of pregnant women and newborns.The levels of APTT,PT,and INR in the study group after treatment were(28.62±4.05)s,(12.37±1.64)s,and 1.09±0.10,respectively,which were higher than those in the control group;and the levels of FIB,ESR,CRP,and PCT were(2.27±0.68)g/L,(18.92±2.15)mm/h,(12.73±2.26)mg/L,and(0.64±0.12)ng/mL,respectively,which were lower than those in the control group(P＜0.001).After treat-ment,the adverse outcomes of pregnant women and newborns in the study group were 5.66％,which were lower than those in the control group(20.75％and 18.87％,respectively)(P＜0.05).There was no significant difference in the incidence of adverse reactions between the two groups during treatment(P＞0.05).The application of ceftriaxone sodium combined with penicillin in the treatment of GBS infection in late pregnancy can improve coagulation function and the levels of ESR,CRP,and PCT,reduce adverse outcomes in pregnant women and newborns,and has high safety.
ceftriaxone sodiumpenicillinlate pregnancygroup B Streptococcal infectionblood coagulation functionmaternal and infant outcome
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