Curative Effect of Xintongshu Combined with Rosuvastatin and its Influences on Blood Lipid,Serum ET-1 and NO in Patients with Unstable Angina Pectoris of Coronary Heart Disease
To explore the curative effect of xintongshu combined with rosuvastatin and its influences on blood lipid,serum endothe-lin-1(ET-1)and nitric oxide(NO)in patients with unstable angina pectoris of coronary heart disease,a total of 108 patients with unstable angina pectoris of coronary heart disease who were treated in Tangshan Hospital of Traditional Chinese Medicine were enrolled as the research objects between January 2019 and January 2022.According to random number table method,they were divided into routine group(rosuvastatin treatment)and combination group(xintongshu combined with rosuvastatin treatment),54 cases in each group.The clinical curative effect and occurrence of adverse reactions,levels of blood lipid indexes[total cholesterol(TC),triglyceride(TG),high-density lipoprotein cholesterol(HDL-C),low-density lipoprotein cholesterol(LDL-C)],serum hypersensi-tive C-reactive protein(hs-CRP),ET-1 and NO,scores of TCM syndromes and echocardiogram indexes[left ventricular ejection fraction(LVEF),left ventricular end-diastolic diameter(LVEDD),left ventricular end-systolic diameter(LVESD)]were compared between the two groups before and after treatment for 30 days.The total response rate of clinical treatment in combination group was higher than that in routine group(P＜0.05).During treatment,the difference in total incidence of adverse reactions between combi-nation group and routine group was not statistically significant(P＞0.05).After treatment,scores of TCM syndromes,LVEDD,LVESD,TC,TG,LDL-C,hs-CRP and ET-1 levels in combination group were lower than those in routine group,while LVEF,HDL-C and NO levels were higher than those in routine group(P＜0.05).The clinical curative effect of xintongshu combined with rosuvas-tatin is significant in patients with unstable angina pectoris of coronary heart disease,which can reduce levels of blood lipid and inflammatory factors,improve vascular endothelial function and cardiac function,and alleviate clinical symptoms,with low incidence of adverse reactions.
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