Clinical Study of Alogliptin Combined with Insulin Glargine in the Treat-ment of the Elderly with Low C-peptide LADA
In order to explore the clinical curative effect of alogliptin combined with insulin glargine in the elderly with low C-peptide latent autoimmune diabetes in adults(LADA),142 elderly patients with with low C-peptide LADA in Qinhuangdao Second Hospital were enrolled as the research objects between May 2020 and May 2023.According to random number table method,they were divided into observation group(n=71)and control group(n=71).The control group was treated with insulin glargine,while observation group was treated with alogliptin+insulin glargine for 6 months.The curative effect,glucose metabolism indexes,islet function,lipid metabolism indexes and adverse reactions in the two groups were compared before and after treatment.The total response rate in observation group was 91.55％(65/71),higher than that in control group[78.87％(56/71),P＜0.05].After 6 months of treat-ment,glycated hemoglobin(HbA1c),fasting blood glucose(FBG)and 2 h postprandial blood glucose(2hPG)were decreased in both groups,which were lower in observation group than those in control group(P＜0.05).After 6 months of treatment,levels of islet β cell function index(HOMA-β)and fasting C-peptide were increased in both groups,which were higher in observation group than those in control group(P＜0.05).After 6 months of treatment,insulin resistance index(HOMA-IR)was decreased in both groups,which was lower in observation group than that in control group(P＜0.05).After 6 months of treatment,low-density lipoprotein cholesterol(LDL-C),triglyceride(TG)and total cholesterol(TC)were decreased in both groups,which were lower in observation group than those in control group(P＜0.05).There was no significant difference in the incidence of adverse reactions between the two groups[9.87％(7/71)vs 7.05％(5/71),P＞0.05].Alogliptin combined with insulin glargine can regulate glucose metabolism,promote reco-very of lipid metabolism and improve islet function in elderly patients with low C-peptide LADA,which has significant curative effect.
latent autoimmune diabetes in adultelderlyalogliptininsulin glargineC-peptideglucose metabolismislet functionlipid metabolism
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