CAR-T细胞治疗肿瘤领域研究进展
Research Progress in the Field of CAR-T Cell Therapy for Tumor Treat-ment
彭正康 1黄育婷 1任瑞 1钟渚永 1段齐阳 1潘家宇 1邱黄珺 1袁纹秀 1李谦1
作者信息
- 1. 中国药科大学生命科学与技术学院,江苏南京 211198
- 折叠
摘要
近年来嵌合抗原受体T细胞(chimeric antigen receptor T-cell,CAR-T)技术在肿瘤治疗领域取得了巨大的成功,其通过体外对T细胞进行修饰转基因扩增后输入人体,经过特异性识别对肿瘤细胞进行杀伤.虽然CAR-T细胞治疗在血液瘤中取得显著的疗效,但在实体瘤中疗效欠佳,文章主要整理近年来国内外学者在CAR-T细胞治疗领域的最新进展,包括在血液瘤、实体瘤以及CAR-T联用新技术方面,对其为提高CAR-T治疗效果所做的工作进行综述.
Abstract
In recent years,chimeric antigen receptor T-cell(CAR-T)therapy has achieved significant success in the field of oncology.This treatment involves genetically modifying T cells ex vivo to express a chimeric antigen receptor,which allows for the targeted expansion and subsequent infusion into the patient's body to specifically recognize and eliminate tumor cells.Although CAR-T therapy has demonstrated remarkable efficacy in hematological malignancies,its effectiveness in solid tumors has been less satisfactory.This article primarily consolidates the latest advancements in CAR-T cell therapy,both domestically and internationally,including developments in the treatment of hematological and solid tumors,as well as the integration of new technologies with CAR-T therapy.It provides an overview of the work conducted to enhance the therapeutic outcomes of CAR-T treatments.
关键词
嵌合抗原受体T细胞/血液瘤/实体瘤/联合治疗/抗体药物/生物纳米材料/溶瘤病毒Key words
CAR-T/hematological tumor/solid tumor/combined therapy/antibody drugs/bio-nanomaterials/oncolytic viruses引用本文复制引用
出版年
2024
NETL
NSTL
万方数据