摘要
探讨外周炎症指标对接受R-CHOP治疗弥漫性大B细胞淋巴瘤(DLBCL)患者预后的预测作用.选取2019年1月至2023年1月间接受R-CHOP方案治疗的96例DLBCL患者进行了回顾性分析,收集患者的基线特征、临床资料、检验资料等资料,并进行随访观察.计量资料两组间比较采用t检验,计数资料两组间比较采用x2检验.采用Kaplan-Meier生存曲线分析不同指标对DLBCL患者预后生存时间的影响,采用单因素和多因素Cox回归分析NLR、PLR、LMR对在预测接受R-CHOP治疗DLBCL患者预后的价值,使用ROC曲线对NLR、PLR、LMR预测价值进行评估.在随访5～43个月、中位随访时间为23.5个月的研究中,共有29例患者死亡.单因素Cox回归分析,结果显示,年龄、Ann Arbor分期、IPI评分、NLR、PLR、LMR、PS评分均与OS相关(P值均＜0.05);将单因素Cox回归分析中有统计学意义的变量纳入多因素Cox回归分析,结果显示,Ann Arbor分期、IPI评分、NLR、PLR、LMR是患者OS的独立影响因素(P＜0.05).ROC曲线结果显示,NLR、PLR、LMR对DLBCL患者预后具有预测价值.NLR、PLR、LMR等外周炎症指标对接受R-CHOP治疗DLBCL患者的预后具有良好的预测价值,这些标志物可以为临床医生做出治疗决策和监测患者结果提供有价值的信息.
Abstract
To investigate the predictive role of peripheral inflammatory markers in the prognosis of patients with diffuse large B-cell lymphoma(DLBCL)undergoing R-CHOP therapy,a retrospective analysis was conducted on 96 patients with DLBCL treated with the R-CHOP protocol between January 2019 and January 2023.Baseline characteristics,clinical data,and laboratory tests were collected from the patients,and follow-up observations were conducted.The t-test was used to compare continuous variables between groups,while the x2 test was employed for categorical variables.Kaplan-Meier survival curves were utilized to assess the impact of various markers on the prognostic survival time of DLBCL patients.Both univariate and multivariate Cox regression analyses were per-formed to evaluate the predictive value of NLR,PLR,and LMR in predicting the prognosis of DLBCL patients receiving R-CHOP therapy.Additionally,ROC curves were employed to assess the predictive value of NLR,PLR,and LMR.During the follow-up period ranging from 5 to 43 months,with a median follow-up time of 23.5 months,29 patients succumbed to the disease.Univariate Cox regression analysis revealed significant associations between age,Ann Arbor staging,IPI score,NLR,PLR,LMR,and PS score with overall survival(OS)(all P＜0.05).Variables with statistical significance in the univariate analysis were then included in the multivariate Cox regression analysis,which demonstrated that Ann Arbor staging,IPI score,NLR,PLR,and LMR were independent predictors of OS(P＜0.05).Furthermore,ROC curve analysis demonstrated the predictive value of NLR,PLR,and LMR in the prognosis of DLBCL patients.In conclusion,peripheral inflammatory markers such as NLR,PLR,and LMR exhibit promising predic-tive value in the prognosis of DLBCL patients undergoing R-CHOP therapy.These biomarkers provide valuable information to clini-cians in making treatment decisions and monitoring patient outcomes.
基金项目
安徽省重点研究与开发计划项目(2022e07020022)
NETL
NSTL
万方数据