Study on the Predictive Value of Combined Detection of Angiogenesis Markers and Cardiovascular Function Indexes in Preeclampsia
To explore the predictive value of combined detection of angiogenesis markers and cardiac function indexes in preeclampsia(PE),129 pregnant women with PE(PE group)and 110 healthy pregnant women(control group)were selected as the subjects,and the expression of sFlt-1/PIGF、NT-proBNP were recorded.Results showed:(1)Compared with the control group,the average UTA-PI,and umbilical artery PI in PE group were significantly higher,while the middle cerebral artery PI in PE group was significantly lower,the MAP,TPRI,sFlt-1/PlGF ratio and NT proBNP level in PE group were significantly higher(P＜0.05).SFlt-1/PlGF,NT proBNP and TPRI had the most significant effects on PE.(2)ROC curve(subject working curve)showed that the area under the curve(AUC)of sFlt-1/PlGF,TPRI and NT proBNP were 0.636,0.658 and 0.797 respectively.(3)There was a significant positive corre-lation between fetal right ventricular SRS and SRD,left ventricular SRS and SRD and maternal systolic blood pressure(r=0.562、0.593、0.661、0.716).At the same time,fetal right ventricular SRS and SRD,left ventricular SRS and SRD and maternal NT proBNP were moderately positively correlated.The combined detection of angiogenesis markers and cardiac function indexes has high predictive value for PE,and the level of NT proBNP in maternal peripheral blood is significantly correlated with fetal myocardial malformation(r=0.428、0.493、0.427、0.396).The combined detection of angiogenesis markers and cardiac function indexes has high predictive value for PE.
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