The Effects of DL-3-n-butylphthalide on the Cognitive Function and Serum Levels of Neuron-specific Enolase and S100B in Patients with Acute Ischemic Stroke
To investigate the effects of DL-3-n-butylphthalide on the cognitive function and serum levels of neuron-specific enolase and S100B in patients with acute ischemic stroke,a total of 119 patients with acute ischemic stroke were enrolled from June 2021 to June 2023 and randomly divided into study group(n=59)and control group(n=60).The study group received injection of DL-3-n-butylphthalide for 14 days followed by oral administration of DL-3-n-butylphthalide capsule for 76 days combined with conditional therapy,while the control group only received conditional therapy.The changes of nervous system injury and cognitive function,as well as the serum levels of neuron-specific enolase and S100B were investigated before and after treatment.After 90 days treatment,the degree of nervous system injury and cognitive dysfunction were improved while the serum levels of neuron-specific enolase and S100B were decreased in both of the two groups(P＜0.05).However,the score of National Institute of Health stroke scale was lower while the score of Mini-mental State Examination was higher in patients in the study group than those in the control group(P＜0.05).Moreover,the serum levels of neuron-specific enolase and S100B were decreased more significantly in patients treated with DL-3-n-butylphthalide when compared to those without DL-3-n-butylphthalide treatment(P＜0.01).Taken together,the authors'study indicates that DL-3-n-butylphthalide could improve the cognitive dysfunction and decrease the biomarkers of neurologi-cal injury in patients with acute ischemic stroke.Further prospective multicenter studies and molecular studies will be needed to confirm the effects and the underlying mechanism of DL-3-n-butylphthalide on the treatment of patients with acute ischemic stroke.
DL-3-n-butylphthalideAcute ischemic strokeNeuron-specific enolaseS100B protein
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