difelikefalin治疗血液透析相关皮肤瘙痒的研究进展
Progress of Difelikefalin in the Treatment of Hemodialysis Pruritus
韩清霞 1杜静 2赵战云2
作者信息
- 1. 山东第二医科大学,山东潍坊 261000
- 2. 潍坊市人民医院肾脏病医学中心,山东潍坊 261000
- 折叠
摘要
血液透析患者的常见并发症之一即皮肤瘙痒,不仅影响患者的身心健康、增加死亡风险,也为患者家庭、医护人员及社会带来了巨大负担.瘙痒的发病机制有多种假说存在,但目前仍未有定论,针对该并发症的治疗也缺少针对性策略.文章主要就FDA新近批准药物difelikefalin治疗血液透析相关皮肤瘙痒的生理机制、治疗进展等作一综述.
Abstract
One of the common complications of hemodialysis patients was pruritus,not only affected the physical and mental health of the patients and increased the risk of mortality,but also imposed a significant burden on patients'families,healthcare providers,and society.Various hypotheses regarding the pathogenesis of pruritus existed,but the jury was still out.There was also a lack of targeted strategies for the treatment of this complication.The physiological mechanism and progress of difelikefalinof FDA recently approved the drug in the treatment of hemodialysis-related pruritus were reviewed in this article.
关键词
慢性肾脏病相关性瘙痒症/地非法林/肾透析/药物治疗Key words
Chronic kidney disease-associated pruritus/Difelikefalin/Kidney dialysis/Pharmacotherapy引用本文复制引用
出版年
2024
NETL
NSTL
万方数据