Analysis of Relationship between NLR,PLR and Tumor Markers,Clini-cal Features in Patients with Gastric Cancer
The aim of this study was to explore the relationship of neutrophil-to-lymphocyte ratio(NLR)and platelet-to-lymphocyte ratio(PLR)with tumor markers[human epidermal growth factor receptor 2(HER-2),Ki-67 protein,P53 protein]and clinical features in patients with gastric cancer.110 patients with gastric cancer in the hospital from July 2018 to June 2021 were selected and included in gastric cancer group,and 80 healthy subjects with physical examination were enrolled as healthy group.The levels of NLR and PLR were compared between groups of subjects.ROC curve was used to analyze the predictive value of NLR and PLR on gastric cancer.The tumor tissues samples of patients with gastric cancer were collected,and the expressions of HER-2,Ki-67 and P53 were detected by immunohistochemistry.The correlation between NLR,PLR and HER-2,Ki-67,P53 and clinical features was analyzed.After 2 years of follow-up,the relationship between NLR and PLR levels and prognosis of patients with gastric cancer was analyzed.The levels of NLR and PLR in gastric cancer group were significantly higher than those in healthy group(all P＜0.05).ROC curve showed that the AUCs of NLR and PLR in the diagnosis of gastric cancer were 0.719 and 0.794 respectively(all P＜0.05).There were statistically significant differences in tumor diameter,differentiation degree,TNM staging,depth of invasion and lymph node metastasis between high NLR(PLR)group and low NLR(PLR)group(all P＜0.05).The levels of NLR and PLR were positively correlated with the expressions of HER-2,Ki-67 and P53(all P＜0.05).The total survival rate of patients in high PLR group was significantly lower compared with that in low PLR group.NLR and PLR have high diagnostic value on gastric cancer,the higher the levels,the higher the positive rates of HER-2,Ki-67 and P53 in gastric cancer patients,the larger the tumor diameter,the greater the possibility of lymph node metastasis,the lower the degree of differentiation,the higher the TNM stage,the deeper the depth of inva-sion,the higher the PLR level,and the worse the prognosis.
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