Mechanism of Silymarin Regulating Intestinal Flora to Protect the Intes-tinal Barrier of NAFLD Patients
To investigate the mechanism of action of silymarin in protecting the intestinal barrier in patients with non-alcoholic fatty liver disease by modulating intestinal flora,a total of 96 cases of NAFLD patients admitted to the hospital during the period of May 2022 to May 2023 who were confirmed by clinical diagnosis were selected,and they were divided into the control group and the observation group by single number and double number.The control group was treated with dicyclomine on the basis of conventional treatment,while the observation group was treated with silymarin on the basis of the control group.The clinical efficacy,liver func-tion,inflammatory factor level,intestinal barrier function,intestinal flora,and statistical adverse reactions were compared between the 2 groups.After the intervention,the total effective rate of treatment in the observation group was significantly higher in 47 cases(97.92％)compared with 40 cases(83.33％)in the control group;the levels of glutamic transaminase(AST),alanine amin-otransferase(ALT),glutamyltranspeptidase(GGT),serum interleukin-6(IL-6),serum interleukin-8(IL-8),tumour necrosis factor-α(TNF-α),lipopolysaccharide(LPS),serum diamine oxidase(DAO)and D-lactic acid(D-LA),were improved to a greater extent in the observation group(P＜0.05).α-diversity results showed,compared with the control group,the Chao 1 index(Chao 1)of the observation group was significantly lower than that of the control group,while the Shannon diversity index(Shannon index)was significantly higher than that of the control group(P＜0.05);the intestinal flora of Bifidobacterium spp.and Lactobacillus spp.in the observation group was significantly higher than that of the control group,whereas Escherichia coli was lower in comparison with the control group(P＜0.05).Regarding the incidence of adverse reactions,the observation group was significantly lower than the control group.The application of silymarin in patients with NAFLD has high therapeutic value and a better effect on the improvement of liver function.It can play a protective effect on the intestinal barrier,and can reduce the occurrence of adverse reactions in patients.
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