The Predictive Value of Hemoglobin in the Severity of Recurrent Ulcera-tive Colitis not Treated with Biological Agents
The objective of this study was to investigate the predictive value of hemoglobin in determining the severity of recurrent ulcerative colitis(RUC)in patients who were not treated with biologics.The methods involved a retrospective analysis of clinical data from RUC patients at the hospital who did not receive biological agents.Based on the modified Mayo score,the patients were catego-rized into low-risk and high-risk groups for comparison of baseline data.The correlation between baseline data and the severity of RUC,as indicated by the modified Mayo score,was then analyzed.Various statistical models,including binary logistic regression and linear regression,were employed to assess the predictors of RUC severity.The predictive value of these factors was further evaluated using receiver operating characteristic(ROC)curve analysis.A total of 94 RUC patients meeting the criteria were included,with 54 males(57.45％)and an average age of(46.43±14.67)years.There were 29 patients in the high-risk group(30.85％)and 65 in the low-risk group(69.15％).There were statistically significant differences in hospitalization days,modified Mayo score,hemo-globin,platelet count,C-reactive protein,erythrocyte sedimentation rate,D-dimer,fibrinogen,and albumin levels among different risk groups of RUC(P＜0.05).Correlation analysis showed that hospitalization days,platelets,C-reactive protein,erythrocyte sedimenta-tion rate,D-dimer,and fibrinogen were positively correlated with the severity of RUC and modified Mayo score(P＜0.05),while hemoglobin and albumin were negatively correlated with the severity of RUC and modified Mayo score(P＜0.001).Binary logistic regression analysis indicated that hemoglobin was an independent predictor of the severity of RUC(P=0.003).Linear regression analysis showed that hemoglobin and albumin were independent predictors of the modified Mayo score in RUC patients(P＜0.05).ROC analysis demonstrated that although hemoglobin,erythrocyte sedimentation rate,albumin,C-reactive protein,D-dimer,platelet count,and fibrinogen could all predict the severity of RUC,hemoglobin had the highest diagnostic value(AUC=0.879,P＜0.001).In conclusion,hemoglobin exhibited moderate predictive value for determining the severity of RUC and modified Mayo score in patients not treated with biological agents.This study highlights the potential utility of hemoglobin as a prognostic marker in the management of recurrent ulcerative colitis.
Ulcerative colitisRecurrent ulcerative colitisDegree of disease activityHemoglobinModified Mayo scoreBiological agents
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