Effect of Compound Danshen Injection Regulating TLRs/MyD88/NF-κB Signaling Pathway on Inflammatory Factors and Plaque Properties in Patients with Angina Pectoris of Coronary Heart Disease
To investigate the effects of compound dansen injection regulating Toll-like receptors(TLRs)/myeloid differentiation pri-mary response 88(MyD88)/nuclear factor-KB(NF-κB)signaling pathway on inflammatory factors and plaque properties in patients with coronary heart disease and angina pectoris,a total of 124 patients with angina pectoris with coronary heart disease admitted to the hospital from May 2021 to May 2023 were included,and were divided into conventional group and compound dansen group with 62 patients in each group according to random number table method.The conventional group was given conventional treatment,and the compound dansen group was given compound dansen injection on the basis of conventional treatment.The treatment effect,frequency and duration of angina pectoris were compared between the two groups.Serum levels of tumor necrosis factor-α(TNF-α),hypersensitive C-reactive protein(hs-CRP)and interleukin-6(IL-6)were detected before and after treatment to evaluate the plaque properties,and the expression levels of TLRs2,TLRs4,MyD88 and NF-κB between the two groups were compared,and adverse reac-tions were recorded.The total effective rate of compound danshen group(93.55％)was higher than that of conventional group(79.03％)(P＜0.05).After treatment,the frequency and duration of angina pectoris in two groups were lower than those of before treatment,and the compound dansen group was lower than that of the conventional group(P＜0.05).The expressions of TNF-α,hs-CRP,IL-6,TLRs2,TLRs4,MyD88 and NF-κB in all groups after treatment were lower than those before treatment,and those in compound dansen group were lower than those in conventional group(P＜0.05).The proportion of soft plaque in compound dansen group(14.52％)after treatment was lower than that in conventional group(33.87％)(P＜0.05).The adverse reaction rate of compound dansen group(6.45％)had no difference compared with that of conventional group(3.23％)(P＞0.05).Compound dansen injection can reduce inflammation and improve plaque properties in patients with angina pectoris by inhibiting TLRs/MyD88/NF-κB signaling pathway.
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