Efficacy of Bronchoalveolar Lavage Combined with Topical Medication in the Treatment of Severe Mycoplasma Pneumoniae Pneumonia in Chil-dren and Changes of CT Imaging Features
The aim of this study was to explore the efficacy of bronchoalveolar lavage combined with local medication in the treat-ment of severe mycoplasma pneumoniae pneumonia(MPP)in children,and analyze the changes of CT imaging features.120 children with severe MPP admitted to Department of Pediatric Intensive Care Medicine of the Hospital from August 2021 to April 2023 were collected and divided into control group(n=60)and observation group(n=60)according to the order of admission by random number table method.The control group was given conventional symptomatic treatment,and the observation group was given bron-choalveolar lavage combined with topical medication of budesonide on the basis of the control group.Both groups were treated for 2 weeks.The total clinical effective rate,clinical indicators,pulmonary function indicators,inflammatory factors,chest CT imaging features and adverse reactions were compared between the two groups.After different regimens for treatment,the total clinical effec-tive rate in observation group(91.67％)was significantly higher than that in control group(76.67％)(P＜0.05),and the disap-pearance time of fever,remission time of cough,disappearance time of pulmonary rales and hospital stay with(3.22±1.19)d,(5.08±1.37)d,(6.64±1.31)d and(11.91±2.63)d were significantly shorter than(5.07±1.63)d,(7.44±1.80)d,(9.45±1.57)d and(15.03±3.48)d in control group(P＜0.05).After treatment,the pulmonary function indicators of FEV,,FVC and PEF in observation group were(1.79±0.34)L,(2.42±0.55)L and(4.75±0.59)Us,which were higher than those in control group(P＜0.05).The inflammatory factors of CRP,PCT and IL-6 in observation group after treatment were(7.91±2.04)mg/L,(0.33±0.12)μg/L and(20.86±4.20)ng/L,which were lower than those in control group(P＜0.05).After treatment,the CT imaging features of both groups were significantly changed,and the features were better in observation group compared to control group(P＜0.05).However,the incidence of adverse reactions in observation group(15.00％)was significantly higher compared with that in control group(P＜0.05).Bronchoalveolar lavage combined with topical medication has significant effi-cacy in the treatment of severe MPP in children,and it can effectively alleviate the clinical symptoms,enhance the lung function,reduce the inflammatory factors,and significantly improve the chest CT imaging features of children,but it is still necessary to pay attention to the use of bronchoscopy.
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