Diabetic retinopathy(DR)has become a major threat to vision in diabetes.Abnormal expression of vascular endothelial growth factor(VEGF)is considered to be the core pathological mechanism of DR.Intravitreal injection of anti-VEGF drugs can quickly inhibit neovascularization and reduce vascular permeability,effectively controlling the progression of the disease.Anti-VEGF drugs have been widely used in the treatment for DR,and the number of intravitreal injections for anti-VEGF drugs has been increasing explosively in recent years.Although intravitreal injection of anti-VEGF drugs is a relatively safe treatment method,it can still cause adverse reactions.Therefore,this article will provide an overview of the adverse reactions of intravitreal injection of anti-VEGF drugs in the treatment for DR in both ocular and systemic aspects.