3D打印技术在高度近视伴后巩膜葡萄肿患者眼轴测量中的应用研究
Research on the application of 3D printing technology in axial length measurement of high myopia with posterior scleral staphyloma
张娜 1王文战 1吴艳 2陈亚铮2
作者信息
- 1. 郑州大学第一附属医院眼科 河南省眼科医院,郑州 450052
- 2. 郑州大学第一附属医院医学3D打印中心,郑州 450052
- 折叠
摘要
目的 评估应用 3D打印制作眼模型在高度近视眼轴测量的效果.方法 前瞻性病例系列研究.收集 2023 年 5 月至 2023 年 12 月在郑州大学第一附属医院眼科行后巩膜加固术的高度近视伴后巩膜葡萄肿患者 10 例(10 眼)的临床资料.术前分别通过磁共振扫描(MRI)、核磁共振图像处理软件Mimics、游标卡尺测量 3D打印的眼球实体模型三种方法测量眼轴,观察记录MRI组、数字模型组及 3D打印组三组数据.三组数据对比采用重复测量方差分析,相关性检验采用Pearson相关分析;一致性检验采用组内相关系数(ICC)分析以及Bland-Altman分析,观察三组间测量眼轴长度的相关性及一致性,评估 3D打印眼模型眼轴测量结果的应用效果.结果 MRI组测量的眼轴平均长度为(28.99±2.68)mm,数字模型组为(28.93±2.67)mm,3D打印组为(29.05±2.65)mm.经重复测量方差分析,三组间差异均无统计学意义(F=1.68,P=0.271).Pearson相关分析结果示:MRI组与数字模型组、MRI组与 3D打印组、数字模型组与 3D打印组的眼轴测量值间均存在线性关系,具有较高的相关性(r=0.993、0.995、0.995;均P<0.001);Bland-Altman分析结果显示:MRI组与数字模型组、MRI组与 3D打印组、数字模型组与 3D打印组测量的眼轴数据一致性均良好,并具有可互换性.结论 3D打印技术制作的眼模型在高度近视伴后巩膜葡萄肿患者眼轴测量与MRI及数字模型一致性和相关性高.
Abstract
Objective To evaluate the effectiveness of using 3D printing technology to create ocular models for the measurement of axial length in high myopia.Methods A study of prospective case series was conducted.Clinical data includes 10 patients(10 eyes)with high myopia with posterior scleral staphyloma who underwent posterior scleral reinforcement surgery in the First Affiliated Hospital of Zhengzhou University from May 2023 to Dec.2023 were collected.Axial length measurements were obtained preoperatively through magnetic resonance imaging(MRI),using the MRI image processing software Mimics,and via physical 3D-printed eyeball models measured with vernier calipers.Data from three groups—MRI,digital model,and 3D-printed model—were observed and recorded.Repeated measures analysis of variance(ANOVA)was used to compare the data among the three groups.Pearson correlation analysis was employed to assess correlation,while intra-class correlation coefficient(ICC)and Bland-Altman analysis were utilized to evaluate the consistency of axial length measurements across the three groups,thereby assessing the application effectiveness of the 3D-printed ocular model for axial length measurements.Results The measurement of mean axial length were(28.99±2.68)mm in the MRI group,(28.93±2.67)mm in the digital model group,and(29.05±2.65)mm in the 3D-printed model group.Repeated measures ANOVA revealed no statistically significant differences among the three groups(F=1.68,P=0.271)in assessing axial length.Pearson correlation analysis showed that scatter plots of axial length measurements between the MRI and digital model groups,MRI and 3D-printed model groups,and digital model and 3D-printed model groups all formed straight lines,indicating a highly significant linear relationship and strong correlation among the three sets of data(r=0.993,0.995,0.995;all P<0.001).Bland-Altman analysis further confirmed good consistency and interchangeability of axial length measurements across the three groups.Conclusion Ophthalmic 3D printed models are highly consistent and correlated with MRI and digital model in measuring the axial length for posterior scleral staphyloma patients with high myopia.
关键词
3D打印/眼科学/生物打印/磁共振成像/高度近视/眼轴长度/后巩膜加固术Key words
3D printing/Ophthalmology/Bioprinting/Magnetic resonance imaging/High myopia/Axial length of the eye/Posterior scleral reinforcement,PSR引用本文复制引用
基金项目
河南省医学教育研究项目(Wjlx2021275)
河南省科学技术厅 2022年度河南省高层次人才国际化培养资助项目(豫科 2022 3号)
郑州大学第一附属医院 2023年度"十年千人"出国人才培养计划项目()
郑州大学第一附属医院新技术新项目(2023-C14-XJS)
出版年
2024
NETL
NSTL
万方数据