微针在经皮药物递送系统中的应用
The Application of Microneedles in Transdermal Drug Delivery Systems
赵翰卿 1陈明龙 2卢安琪 3李莹莹 1王清清1
作者信息
- 1. 蚌埠医科大学药学院,安徽蚌埠 233000
- 2. 中国科学院软物质化学重点实验室中国科学技术大学高分子科学与工程系,安徽合肥 230026
- 3. 中山大学药学院,广东广州 510006
- 折叠
摘要
作为经皮给药系统中新兴和高效递送形式的微针,可以定向突破角质层对药物吸收的限制.微针具有微创、无痛、高适应性和控释药物的优点,在生物医学经皮给药领域具有广阔的应用前景.综述主要总结近年来微针发展历程和研究进展,系统讨论了各种微针类型在应用时的优缺点,重点介绍微针制备技术在生物医学领域的研究进展,为微针的进一步开发利用提供相关参考.
Abstract
Microneedles,as an emerging and efficient delivery system in transdermal drug delivery,can selectively penetrate the stratum comeum to overcome the limitations of drug absorption.They have such advantages as minimal invasiveness,painlessness,high compliance,and controlled release,with broad prospects in the field of biomedical transdermal drug delivery.This review briefly summarizes the development and research progress of microneedles in recent years,systematically discusses the advantages and disadvantages of various types of microneedles in medical application,and particularly introduces the research progress of microneedle preparation technology in the biomedical field,in order to provide some reference for the further development and application of microneedles.
关键词
微针/经皮给药/制备技术/微针类型Key words
microneedle/transdermal drug delivery/preparation technology/microneedle type引用本文复制引用
基金项目
安徽省自然科学基金(2108085MH317)
安徽省博士后研究人员科研活动项目(2022B626)
出版年
2024
NETL
NSTL
万方数据