New Progress in HIV-1 Reverse Transcriptase Inhibitors(2021-2023)
Reverse transcriptase(RT),which reverse-transcribes viral single-stranded RNA into double-stranded DNA,plays an irreplaceable role in the replication cycle of human immunodeficiency virus type 1(HIV-1).Reverse transcriptase inhibitors(RTIs),a key component of highly active antiretroviral therapy(HAART),have achieved great success in the treatment of AIDS,drastically reducing the morbidity and mortality of HIV-infected patients.However,with the long-term application of RTIs in clinic,many problems,such as drug resistance and adverse reaction,have gradually emerged.Therefore,it is of great significance to develop novel HIV-1 RTIs with high efficiency,low toxicity and anti-drug resistance.In this review,the latest research progress of anti-AIDS drugs and related drug candidates targeting HIV-l RT in the past three years is summarized,aiming to provide some reference for further research and development of novel RTIs.
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